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P62993 Proteins SH3 domain Repeats
Uniprot ID:P62993
Protein name: Growth factor receptor-bound protein 2
Gene : GRB2 ASH
Protein Family:GRB2/sem-5/DRK family
Squence Length : 217
Sequnce
>P62993 218 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
Domains
DOMAIN 1 58 SH3 1 DOMAIN 60 152 SH2 DOMAIN 156 215 SH3 2
SH3 sequence regions
1 - 58 AIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW 156 - 215 PTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
Function
"Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.; Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death"
Mutation
49 49 P->L: Ineffective in DNA synthesis when associated with L-206 89 89 E->K: No effect on the interaction with SOS1 90 90 S->N: No effect on the interaction with SOS1 203 203 G->R: Ineffective in DNA synthesis 206 206 P->L: Abolishes interaction with SHB when associated with L-49