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P81274 Proteins GoLoco domain Repeats
Uniprot ID:P81274
Protein name: G-protein-signaling modulator 2
Gene : GPSM2 LGN
Protein Family:GPSM family
Squence Length : 684
Sequnce
>P81274 685 MEENLISMREDHSFHVRYRMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLGLSYSTNNSIMSENTEIDSSLNGVRPKLGRRHSMENMELMKLTPEKVQNWNSEILAKQKPLIAKPSAKLLFVNRLKGKKYKTNSSTKVLQDASNSIDHRIPNSQRKISADTIGDEGFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTSSTPPKMMLKTSSVPVVSPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTQNSQSVLSHLMTNDNKEADEDFFDILVKCQGSRLDDQRCAPPPATTKGPTVPDEDFFSLILRSQGKRMDEQRVLLQRDQNRDTDFGLKDFLQNNALLEFKNSGKKSADH
Domains
DOMAIN 489 511 GoLoco 1 DOMAIN 544 566 GoLoco 2 DOMAIN 594 616 GoLoco 3 DOMAIN 628 650 GoLoco 4
GoLoco sequence regions
489 - 511 GFFDLLSRFQSNRMDDQRCCLQE 544 - 566 EFLDLLASSQSRRLDDQRASFSN 594 - 616 DFFDILVKCQGSRLDDQRCAPPP 628 - 650 DFFSLILRSQGKRMDEQRVLLQR
Function
"Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays also an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity)"
Binding Site
BINDING 608 608 GDP. shared with dimeric partner. BINDING 613 613 GDP. shared with dimeric partner. BINDING 642 642 GDP. shared with dimeric partner. BINDING 647 647 GDP. shared with dimeric partner
Mutation
228 228 R->A: Abolishes location at mitotic spindle poles when associated with A-243 228 228 R->E: Strongly reduces interaction with INSC when associated with R-290 243 243 R->A: Abolishes location at mitotic spindle poles when associated with A-228 290 290 N->R: Abolishes interaction with INSC when associated with E-228
Disease
"DISEASE: Chudley-McCullough syndrome (CMCS) [MIM:604213]: An autosomal recessive neurologic disorder characterized by early-onset sensorineural deafness and specific brain anomalies on MRI, including hypoplasia of the corpus callosum, enlarged cysterna magna with mild focal cerebellar dysplasia, and nodular heterotopia Some patients have hydrocephalus Psychomotor development is normal Note=The disease is caused by mutations affecting the gene represented in this entry"