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P98155 Proteins EGF-like domain Repeats
Uniprot ID:P98155
Protein name: Very low-density lipoprotein receptor
Gene : VLDLR
Protein Family:
Squence Length : 873
Sequnce
>P98155 874 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
Domains
DOMAIN 31 69 LDL-receptor class A 1 DOMAIN 70 110 LDL-receptor class A 2 DOMAIN 111 151 LDL-receptor class A 3 DOMAIN 152 190 LDL-receptor class A 4 DOMAIN 191 231 LDL-receptor class A 5 DOMAIN 237 275 LDL-receptor class A 6 DOMAIN 276 314 LDL-receptor class A 7 DOMAIN 316 355 LDL-receptor class A 8 DOMAIN 356 395 EGF-like 1 DOMAIN 396 435 EGF-like 2 calcium-binding DOMAIN 702 750 EGF-like 3
EGF-like sequence regions
356 - 395 NECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDI 396 - 435 DECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV 702 - 750 NWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQST
Function
"Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity)"
Motifs
MOTIF 832 837 Endocytosis signal
Mutation
825 825 K->R: Insensitive to MYLIP-triggered degradation when associated with R-828 and R-839 828 828 K->R: Insensitive to MYLIP-triggered degradation when associated with R-825 and R-839 839 839 K->R: Insensitive to MYLIP-triggered degradation when associated with R-825 and R-828
Disease
"DISEASE: Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 1 (CAMRQ1) [MIM:224050]: A congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation, cerebellar hypoplasia and mild cerebral gyral simplification Additional features include short stature, strabismus, pes planus and, rarely, seizures Note=The disease is caused by mutations affecting the gene represented in this entry"