Uniprot ID:Q07954	Protein name: Prolow-density lipoprotein receptor-related protein 1	Gene : LRP1 A2MR APR
Protein Family:LDLR family	Squence Length : 4544

Sequnce	>Q07954 4545 MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQPGHIASILIPLLLLLLLVLVAGVVFWYKRRVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPTNFTNPVYATLYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA
Domains	DOMAIN 25 66 LDL-receptor class A 1 DOMAIN 70 110 LDL-receptor class A 2 DOMAIN 111 149 EGF-like 1 DOMAIN 150 189 EGF-like 2 calcium-binding DOMAIN 474 520 EGF-like 3 DOMAIN 803 843 EGF-like 4 DOMAIN 852 892 LDL-receptor class A 3 DOMAIN 893 933 LDL-receptor class A 4 DOMAIN 934 973 LDL-receptor class A 5 DOMAIN 974 1013 LDL-receptor class A 6 DOMAIN 1013 1053 LDL-receptor class A 7 DOMAIN 1060 1099 LDL-receptor class A 8 DOMAIN 1102 1142 LDL-receptor class A 9 DOMAIN 1143 1182 LDL-receptor class A 10 DOMAIN 1183 1222 EGF-like 5 DOMAIN 1223 1262 EGF-like 6 DOMAIN 1536 1579 EGF-like 7 DOMAIN 1846 1887 EGF-like 8 DOMAIN 2155 2195 EGF-like 9 DOMAIN 2478 2518 EGF-like 10 DOMAIN 2522 2563 LDL-receptor class A 11 DOMAIN 2564 2602 LDL-receptor class A 12 DOMAIN 2603 2641 LDL-receptor class A 13 DOMAIN 2642 2690 LDL-receptor class A 14 DOMAIN 2694 2732 LDL-receptor class A 15 DOMAIN 2732 2771 LDL-receptor class A 16 DOMAIN 2772 2814 LDL-receptor class A 17 DOMAIN 2816 2855 LDL-receptor class A 18 DOMAIN 2856 2899 LDL-receptor class A 19 DOMAIN 2902 2940 LDL-receptor class A 20 DOMAIN 2941 2981 EGF-like 11 DOMAIN 2982 3022 EGF-like 12 calcium-binding DOMAIN 3290 3331 EGF-like 13 DOMAIN 3332 3371 LDL-receptor class A 21 DOMAIN 3372 3410 LDL-receptor class A 22 DOMAIN 3411 3450 LDL-receptor class A 23 DOMAIN 3451 3491 LDL-receptor class A 24 DOMAIN 3492 3533 LDL-receptor class A 25 DOMAIN 3534 3572 LDL-receptor class A 26 DOMAIN 3573 3611 LDL-receptor class A 27 DOMAIN 3611 3649 LDL-receptor class A 28 DOMAIN 3652 3692 LDL-receptor class A 29 DOMAIN 3693 3733 LDL-receptor class A 30 DOMAIN 3739 3778 LDL-receptor class A 31 DOMAIN 3781 3823 EGF-like 14 DOMAIN 3824 3861 EGF-like 15 DOMAIN 4147 4183 EGF-like 16 DOMAIN 4196 4232 EGF-like 17 DOMAIN 4232 4268 EGF-like 18 DOMAIN 4268 4304 EGF-like 19 DOMAIN 4304 4340 EGF-like 20 DOMAIN 4340 4375 EGF-like 21 DOMAIN 4373 4409 EGF-like 22
LDL-receptor class A sequence regions	25 - 66 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSK 70 - 110 CQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQ 852 - 892 CQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHT 893 - 933 CPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSART 934 - 973 CPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPT 974 - 1013 CFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSC 1013 - 1053 CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQA 1060 - 1099 CHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVT 1102 - 1142 CDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLA 1143 - 1182 CRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQ 2522 - 2563 CRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRR 2564 - 2602 CKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTA 2603 - 2641 CGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATD 2642 - 2690 CSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVK 2694 - 2732 CPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFC 2732 - 2771 CSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKT 2772 - 2814 CGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNS 2816 - 2855 CDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPT 2856 - 2899 CGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQE 2902 - 2940 CNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHIN 3332 - 3371 CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFK 3372 - 3410 CRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHV 3411 - 3450 CLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVT 3451 - 3491 CAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMT 3492 - 3533 CGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERT 3534 - 3572 CEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRP 3573 - 3611 CSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRC 3611 - 3649 CDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGV 3652 - 3692 CPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFV 3693 - 3733 CPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPT 3739 - 3778 CKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDP
Function	"Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:11907044, PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438).; (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A"
Motifs	MOTIF 3940 3943 Recognition site for proteolytical processing. MOTIF 4502 4507 NPXY motif
Mutation	4460 4460 T->A: Strongly reduced phosphorylation and loss of interaction with SHC1 when associated with A-4517 A-4520 and A-4523 4470 4473 NPTY->APTA: No effect on tyrosine phosphorylation 4470 4470 N->A: No effect on interaction with GULP1 4472 4472 T->A: No detectable effect on phosphorylation 4504 4507 NPVY->APVA: Loss of tyrosine phosphorylation 4504 4504 N->A: Loss of interaction with GULP1 4517 4517 S->A: Strongly reduced phosphorylation and loss of interaction with SHC1 when associated with A-4460 A-4520 and A-4523 4520 4520 S->A: Strongly reduced phosphorylation and loss of interaction with SHC1 when associated with A-4460 A-4517 and A-4523 4523 4523 S->A: Strongly reduced phosphorylation and loss of interaction with SHC1 when associated with A-4460 A-4517 and A-4520
Disease	"DISEASE: Keratosis pilaris atrophicans (KPA) [MIM:604093]: A group of rare genodermatoses characterized by keratotic follicular papules, variable degrees of inflammation, and secondary atrophic scarring Most cases are associated with an atopic diathesis and keratosis pilaris on the extensor extremities KPA is comprised of three distinct clinical subtypes: keratosis pilaris atrophicans faciei, atrophoderma vermiculatum, and keratosis follicularis spinulosa decalvans Affected individuals may present with features overlapping the 3 subtypes Note=The disease is caused by mutations affecting the gene represented in this entry"

Q07954 Proteins LDL-receptor class A domain Repeats