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Q13087 Proteins Thioredoxin domain Repeats

Uniprot ID:Q13087	Protein name: Protein disulfide-isomerase A2	Gene : PDIA2 PDIP
Protein Family:Protein disulfide isomerase family	Squence Length : 525

Sequnce	>Q13087 526 MSRQLLPVLLLLLLRASCPWGQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDALDMTFGLTDRPRLFQQFGLTKDTVVLFKKFDEGRADFPVDEELGLDLGDLSRFLVTHSMRLVTEFNSQTSAKIFAARILNHLLLFVNQTLAAHRELLAGFGEAAPRFRGQVLFVVVDVAADNEHVLQYFGLKAEAAPTLRLVNLETTKKYAPVDGGPVTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATANELDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLPTEEPPEEPAAPFPEPPANSTMGSKEEL
Domains	DOMAIN 27 152 Thioredoxin 1 DOMAIN 367 496 Thioredoxin 2
Thioredoxin sequence regions	27 - 152 PSEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPS 367 - 496 NGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATANELDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLP
Function	Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins
Active Site	ACT_SITE 71 71 Nucleophile. ACT_SITE 74 74 Nucleophile. ACT_SITE 418 418 Nucleophile. ACT_SITE 421 421 Nucleophile
Motifs	MOTIF 522 525 Prevents secretion from ER
Mutation	18 18 C->A: Impairs interchain disulfide bridge formation 284 284 N->Q: Increases formation of a highly stable disulfide-bonded PDIA2 dimer 364 364 C->A: No effect on interchain disulfide bridge formation