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Q13117 Proteins DAZ-like domain Repeats
Uniprot ID:Q13117
Protein name: Deleted in azoospermia protein 2
Gene : DAZ2
Protein Family:RRM DAZ family
Squence Length : 558
Sequnce
>Q13117 559 MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVITGCQLLVYNYQEYPTYPDSAFQVTTGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQPFPAYPSSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQAFPAYPNSPVQVTTGYQLPVYNYQAFPAYPNSPVQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPNSAVQVTTGYQFHVYNYQMPPQCPVGEQRRNLWTEAYKWWYLVCLIQRRD
Domains
DOMAIN 40 115 RRM DOMAIN 170 190 DAZ-like 1 DOMAIN 194 214 DAZ-like 2 DOMAIN 218 238 DAZ-like 3 DOMAIN 242 262 DAZ-like 4 DOMAIN 266 286 DAZ-like 5 DOMAIN 290 310 DAZ-like 6 DOMAIN 314 334 DAZ-like 7 DOMAIN 338 358 DAZ-like 8 DOMAIN 362 382 DAZ-like 9 DOMAIN 386 406 DAZ-like 10 DOMAIN 410 430 DAZ-like 11 DOMAIN 434 454 DAZ-like 12 DOMAIN 458 478 DAZ-like 13 DOMAIN 482 502 DAZ-like 14 DOMAIN 506 526 DAZ-like 15
DAZ-like sequence regions
170 - 190 PHSPGQVITGCQLLVYNYQEY 194 - 214 PDSAFQVTTGYQLPVYNYQPF 218 - 238 PRSPFQVTAGYQLPVYNYQAF 242 - 262 PNSPFQVATGYQFPVYNYQPF 266 - 286 PSSPFQVTAGYQLPVYNYQAF 290 - 310 PNSPFQVATGYQFPVYNYQAF 314 - 334 PNSPVQVTTGYQLPVYNYQAF 338 - 358 PNSPVQVTTGYQLPVYNYQAF 362 - 382 PSSPFQVTTGYQLPVYNYQAF 386 - 406 PSSPFQVTTGYQLPVYNYQAF 410 - 430 PSSPFQVTTGYQLPVYNYQAF 434 - 454 PSSPFQVTTGYQLPVYNYQAF 458 - 478 PSSPFQVTTGYQLPVYNYQAF 482 - 502 PSSPFQVTTGYQLPVYNYQAF 506 - 526 PNSAVQVTTGYQFHVYNYQMP
Function
RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation
Disease
"DISEASE: Spermatogenic failure Y-linked 2 (SPGFY2) [MIM:415000]: A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility Note=The disease may be caused by mutations affecting the gene represented in this entry AZFc deletions in the Yq11 23 region including the DAZ genes are the most common known genetic cause of human male infertility"