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Q13247 Proteins RRM domain Repeats
Uniprot ID:Q13247
Protein name: Serine/arginine-rich splicing factor 6
Gene : SRSF6 SFRS6 SRP55
Protein Family:Splicing factor SR family
Squence Length : 344
Sequnce
>Q13247 345 MPRVYIGRLSYNVREKDIQRFFSGYGRLLEVDLKNGYGFVEFEDSRDADDAVYELNGKELCGERVIVEHARGPRRDRDGYSYGSRSGGGGYSSRRTSGRDKYGPPVRTEYRLIVENLSSRCSWQDLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTEINGRNIRLIEDKPRTSHRRSYSGSRSRSRSRRRSRSRSRRSSRSRSRSISKSRSRSRSRSKGRSRSRSKGRKSRSKSKSKPKSDRGSHSHSRSRSKDEYEKSRSRSRSRSPKENGKGDIKSKSRSRSQSRSNSPLPVPPSKARSVSPPPKRATSRSRSRSRSKSRSRSRSSSRD
Domains
DOMAIN 1 72 RRM 1 DOMAIN 110 183 RRM 2
RRM sequence regions
1 - 72 RVYIGRLSYNVREKDIQRFFSGYGRLLEVDLKNGYGFVEFEDSRDADDAVYELNGKELCGERVIVEHARGPR 110 - 183 LIVENLSSRCSWQDLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTEINGRNIRLIEDKPRT
Function
Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing
Mutation
280 280 S->A: No effect on regulation of alternative splicing of MAPT/Tau exon 10 by DYRK1A 303 303 S->A: Abolishes regulatory effect of DYRK1A on alternative splicing of MAPT/Tau exon 10 316 316 S->A: No effect on regulation of alternative splicing of MAPT/Tau exon 10 by DYRK1A