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Q14190 Proteins PAS domain Repeats
Uniprot ID:Q14190
Protein name: Single-minded homolog 2
Gene : SIM2 BHLHE15
Protein Family:
Squence Length : 667
Sequnce
>Q14190 668 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEAPAAAVRRFGEDTAPPSFPSCGHYREEPALGPAKAARQAARDGARLALARAAPECCAPPTPEAPGAPAQLPFVLLNYHRVLARRGPLGGAAPAASGLACAPGGPEAATGALRLRHPSPAATSPPGAPLPHYLGASVIITNGR
Domains
DOMAIN 1 53 bHLH DOMAIN 77 149 PAS 1 DOMAIN 218 288 PAS 2 DOMAIN 292 335 PAC DOMAIN 336 667 Single-minded C-terminal
PAS sequence regions
77 - 149 ELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLL 218 - 288 SAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQV
Function
Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development
Motifs
MOTIF 367 386 Nuclear localization signal
Mutation
"367 367 R->A,G: Reduced nuclear translocation 368 368 K->A: No effect on nuclear translocation 369 369 L->A: No effect on nuclear translocation 370 370 V->A: No effect on nuclear translocation 371 371 K->A: No effect on nuclear translocation 372 372 P->A: No effect on nuclear translocation 373 373 K->A,G: Reduced nuclear translocation 375 375 T->A: No effect on nuclear translocation 376 376 K->A: No effect on nuclear translocation 377 377 M->A: No effect on nuclear translocation 378 378 K->G: No effect on nuclear translocation 379 379 T->A: No effect on nuclear translocation 380 380 K->A: No effect on nuclear translocation 381 381 L->A: No effect on nuclear translocation 382 382 R->A: No effect on nuclear translocation 383 383 T->A: No effect on nuclear translocation 385 385 P->A: Reduced nuclear translocation 386 386 Y->A: Reduced nuclear translocation"