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Q14192 Proteins LIM zinc-binding domain Repeats
Uniprot ID:Q14192
Protein name: Four and a half LIM domains protein 2
Gene : FHL2 DRAL SLIM3
Protein Family:
Squence Length : 279
Sequnce
>Q14192 280 MTERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI
Domains
DOMAIN 40 92 LIM zinc-binding 1 DOMAIN 101 153 LIM zinc-binding 2 DOMAIN 162 212 LIM zinc-binding 3 DOMAIN 221 275 LIM zinc-binding 4
LIM zinc-binding sequence regions
40 - 92 ECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYS 101 - 153 ECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYE 162 - 212 QCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFC 221 - 275 GCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGK
Function
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008)