Uniprot ID:Q14766	Protein name: Latent-transforming growth factor beta-binding protein 1	Gene : LTBP1
Protein Family:LTBP family	Squence Length : 1721

Sequnce	>Q14766 1722 MAGAWLRWGLLLWAGLLASSAHGRLRRITYVVHPGPGLAAGALPLSGPPRSRTFNVALNARYSRSSAAAGAPSRASPGVPSERTRRTSKPGGAALQGLRPPPPPPPEPARPAVPGGQLHPNPGGHPAAAPFTKQGRQVVRSKVPQETQSGGGSRLQVHQKQQLQGVNVCGGRCCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKACETIAAQDTSSPVFGGQSPGAASSWGPPEQAAKHTSSKKADTLPRVSPVAQMTLTLKPKPSVGLPQQIHSQVTPLSSQSVVIHHGQTQEYVLKPKYFPAQKGISGEQSTEGSFPLRYVQDQVAAPFQLSNHTGRIKVVFTPSICKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHLHPQFPVVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGVGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTALNLEKDSDLE
Domains	DOMAIN 187 219 EGF-like 1 DOMAIN 399 431 EGF-like 2 DOMAIN 557 609 TB 1 DOMAIN 626 663 EGF-like 3 calcium-binding DOMAIN 677 729 TB 2 DOMAIN 873 910 EGF-like 4 calcium-binding DOMAIN 915 956 EGF-like 5 calcium-binding DOMAIN 957 997 EGF-like 6 calcium-binding DOMAIN 998 1037 EGF-like 7 calcium-binding DOMAIN 1038 1078 EGF-like 8 calcium-binding DOMAIN 1079 1119 EGF-like 9 calcium-binding DOMAIN 1120 1160 EGF-like 10 calcium-binding DOMAIN 1161 1201 EGF-like 11 calcium-binding DOMAIN 1202 1243 EGF-like 12 calcium-binding DOMAIN 1244 1281 EGF-like 13 calcium-binding DOMAIN 1286 1328 EGF-like 14 calcium-binding DOMAIN 1347 1401 TB 3 DOMAIN 1424 1466 EGF-like 15 calcium-binding DOMAIN 1467 1503 EGF-like 16 calcium-binding DOMAIN 1524 1577 TB 4 DOMAIN 1621 1657 EGF-like 17 DOMAIN 1662 1706 EGF-like 18 calcium-binding
EGF-like sequence regions	187 - 219 PSCVPPCQNGGMCLRPQLCVCKPGTKGKACETI 399 - 431 VICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIP 626 - 663 NECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 873 - 910 NECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRK 915 - 956 DECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDV 957 - 997 DECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDI 998 - 1037 DECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDV 1038 - 1078 DECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDI 1079 - 1119 DECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDI 1120 - 1160 DECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDI 1161 - 1201 NECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDI 1202 - 1243 NECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDI 1244 - 1281 DECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQG 1286 - 1328 NECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSR 1424 - 1466 DECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDM 1467 - 1503 DECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKR 1621 - 1657 EECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMT 1662 - 1706 NECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPL
Function	"May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM)"
Motifs	MOTIF 1174 1176 Cell attachment site
Mutation	"1348 1348 E->A: Abolishes interaction with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1 when associated with 1382-A--A-1385 1366 1366 N->A,Q: Abolishes N-glycosylation at this site without affecting ability to interact with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1 1382 1385 DNCE->ANCA: Abolishes interaction with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1 when associated with A-1348 1385 1388 EIFP->DL: Loss of binding to TGFB1"

Q14766 Proteins EGF-like domain Repeats