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Q15084 Proteins Thioredoxin domain Repeats

Uniprot ID:Q15084	Protein name: Protein disulfide-isomerase A6	Gene : PDIA6 ERP5 P5 TXNDC7
Protein Family:Protein disulfide isomerase family	Squence Length : 440

Sequnce	>Q15084 441 MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDDLGKDEL
Domains	DOMAIN 20 133 Thioredoxin 1 DOMAIN 154 287 Thioredoxin 2
Thioredoxin sequence regions	20 - 133 SSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLV 154 - 287 SSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKR
Function	"May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936)"
Active Site	ACT_SITE 55 55 Nucleophile. ACT_SITE 58 58 Nucleophile. ACT_SITE 190 190 Nucleophile. ACT_SITE 193 193 Nucleophile
Motifs	MOTIF 437 440 Prevents secretion from ER
Mutation	55 55 C->S: 50% decrease in enzyme activity when associated with S-58 when associated with S-58 S-190 and S-193 58 58 C->A: Accelerates dephosphorylation of ERN1 when associated with A-193 58 58 C->S: 50% decrease in enzyme activity when associated with S-55 when associated with S-193 when associated with S-55 S-190 and S-193 190 190 C->S: 25% decrease in enzyme activity when associated with S-193 when associated with S-55 S-58 and S-193 193 193 C->A: Accelerates dephosphorylation of ERN1 when associated with A-58 193 193 C->S: 90% decrease in enzyme activity when associated with S-58 when associated with S-190 when associated with S-55 S-58 and S-190