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Q15942 Proteins LIM zinc-binding domain Repeats
Uniprot ID:Q15942
Protein name: Zyxin
Gene : ZYX
Protein Family:Zyxin/ajuba family
Squence Length : 572
Sequnce
>Q15942 573 MAAPRPSPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRVGEIPPPPPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEIFPSPPPPPEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATPFSSKSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQPRGPPASSPAPAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHTARAQT
Domains
DOMAIN 384 443 LIM zinc-binding 1 DOMAIN 444 503 LIM zinc-binding 2 DOMAIN 504 570 LIM zinc-binding 3
LIM zinc-binding sequence regions
384 - 443 RCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEKCN 444 - 503 TCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCS 504 - 570 VCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHTARAQT
Function
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity)
Mutation
71 71 F->A: Reduced interaction with ENAH and VASP 93 93 F->A: Reduced interaction with ENAH and VASP 104 104 F->A: Greatly reduced interaction with ENAH and VASP when associated with A-71 or with A-71 and A-93 114 114 F->A: No targeting to focal adhesions and reduced actin-rich structures when associated with A-71 A-93 and A-104