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Q5IJ48 Proteins EGF-like domain Repeats
Uniprot ID:Q5IJ48
Protein name: Protein crumbs homolog 2
Gene : CRB2
Protein Family:Crumbs protein family
Squence Length : 1285
Sequnce
>Q5IJ48 1286 MALARPGTPDPQALASVLLLLLWAPALSLLAGTVPSEPPSACASDPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQNTTFSVMAGSPIQASVPAGGPLGLALRFRTTLPAGTLATRNDTKESLELALVAATLQATLWSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLWHEGCPARLCVASGPVALASTASATPLPAGISSAQLGDATFAGCLQDVRVDGHLLLPEDLGENVLLGCERREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEIPAATFGLGGAPSSASFLLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEVPGSPAVVLPGRWDDGLRHLVMLSFGPDQLQDLGQHVHVGGRLLAADSQPWGGPFRGCLQDLRLDGCHLPFFPLPLDNSSQPSELGGRQSWNLTAGCVSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLWCPGQPCLPPATCEEVPDGFVCVAEATFREGPPAAFSGHNASSGRLLGGLSLAFRTRDSEAWLLRAAAGALEGVWLAVRNGSLAGGVRGGHGLPGAVLPIPGPRVADGAWHRVRLAMERPAATTSRWLLWLDGAATPVALRGLASDLGFLQGPGAVRILLAENFTGCLGRVALGGLPLPLARPRPGAAPGAREHFASWPGTPAPILGCRGAPVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLPLPLPFPLLEVAVPAACACLLLLLLGLLSGILAARKRRQSEGTYSPSQQEVAGARLEMDSVLKVPPEERLI
Domains
DOMAIN 67 106 EGF-like 1 DOMAIN 108 144 EGF-like 2 calcium-binding DOMAIN 146 182 EGF-like 3 calcium-binding DOMAIN 184 221 EGF-like 4 calcium-binding DOMAIN 223 259 EGF-like 5 DOMAIN 261 318 EGF-like 6 DOMAIN 320 356 EGF-like 7 calcium-binding DOMAIN 358 394 EGF-like 8 calcium-binding DOMAIN 396 436 EGF-like 9 DOMAIN 431 603 Laminin G-like 1 DOMAIN 605 641 EGF-like 10 DOMAIN 647 805 Laminin G-like 2 DOMAIN 807 843 EGF-like 11 DOMAIN 871 1054 Laminin G-like 3 DOMAIN 1056 1092 EGF-like 12 DOMAIN 1094 1130 EGF-like 13 DOMAIN 1134 1171 EGF-like 14 DOMAIN 1173 1209 EGF-like 15
EGF-like sequence regions
67 - 106 RGCATQPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELD 108 - 144 DECASRPCHHGATCRNLADRYECHCPLGYAGVTCEME 146 - 182 DECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLD 184 - 221 DECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCERE 223 - 259 LECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVD 261 - 318 DECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVE 320 - 356 DECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEED 358 - 394 DECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQ 396 - 436 TGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQN 605 - 641 EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADE 807 - 843 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQ 1056 - 1092 PVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAH 1094 - 1130 DPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLP 1134 - 1171 KECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVP 1173 - 1209 LPCEANPCLNGGTCRAAGGVSECICNARFSGQFCEVA
Function
"Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo. Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer. The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin-IIB. Also required for maintenance of the apical polarity complex during development of the cortex"
Disease
"DISEASE: Focal segmental glomerulosclerosis 9 (FSGS9) [MIM:616220]: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation Note=The disease is caused by mutations affecting the gene represented in this entry ; DISEASE: Ventriculomegaly with cystic kidney disease (VMCKD) [MIM:219730]: A severe autosomal recessive developmental disorder manifesting in utero It is characterized by cerebral ventriculomegaly, echogenic kidneys, microscopic renal tubular cysts and findings of congenital nephrosis Note=The disease is caused by mutations affecting the gene represented in this entry"