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Q6P5Z2 Proteins REM-1 domain Repeats

Uniprot ID:Q6P5Z2	Protein name: Serine/threonine-protein kinase N3	Gene : PKN3 PKNBETA
Protein Family:"Protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily"	Squence Length : 889

Sequnce	>Q6P5Z2 890 MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSPAAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP
Domains	DOMAIN 5 80 REM-1 1 DOMAIN 93 163 REM-1 2 DOMAIN 165 245 REM-1 3 DOMAIN 559 818 Protein kinase DOMAIN 819 889 AGC-kinase C-terminal
REM-1 sequence regions	5 - 80 RQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSSNRRLEQLHGELRELHARILLPG 93 - 163 PRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISS 165 - 245 EASGSPEPGPELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAH
Function	Contributes to invasiveness in malignant prostate cancer
Active Site	ACT_SITE 684 684 Proton acceptor
Binding Site	BINDING 588 588 ATP
Nucleotide Binding	NP_BIND 565 573 ATP
Mutation	588 588 K->E: Abolishes autophosphorylation and catalytic activity 588 588 K->R: Abolishes catalytic activity 718 718 T->A: Abolishes phosphorylation