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Q6ZMT1 Proteins SH3 domain Repeats
Uniprot ID:Q6ZMT1
Protein name: SH3 and cysteine-rich domain-containing protein 2
Gene : STAC2
Protein Family:
Squence Length : 411
Sequnce
>Q6ZMT1 412 MTEMSEKENEPDDAATHSPPGTVSALQETKLQRFKRSLSLKTILRSKSLENFFLRSGSELKCPTEVLLTPPTPLPPPSPPPTASDRGLATPSPSPCPVPRPLAALKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSEEISHQQCPGKTSTSFRRNFSSPLLVHEPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSESPTRSLSERDELTEDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEKSPGQQLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFSGNKEQGYMSLKENQICVGVGRSKDADGFIRVSSGKKRGLVPVDALTEI
Domains
DOMAIN 292 351 SH3 1 DOMAIN 354 411 SH3 2
SH3 sequence regions
292 - 351 MYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGE 354 - 411 WRCCQPFSGNKEQGYMSLKENQICVGVGRSKDADGFIRVSSGKKRGLVPVDALTEI
Function
"Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C"
Mutation
306 306 Q->L: Mildly decreased affinity for CACNA1S 329 329 W->S: Loss of interaction with CACNA1S 347 347 Q->I: No effect on the structure of the two SH3 domains