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Q6ZTN6 Proteins UIM domain Repeats
Uniprot ID:Q6ZTN6
Protein name: Ankyrin repeat domain-containing protein 13D
Gene : ANKRD13D
Protein Family:
Squence Length : 518
Sequnce
>Q6ZTN6 519 MVQLVLQYRDYQRATQRLAGIPELLNKLRQAPDFYVEMKWEFTSWVPLVSKMCPSDVYRVWKRGESLRVDTSLLGFEHMTWQRGRRSFIFKGQEAGALVMEVDHDRQVVHVETLGLTLQEPETLLAAMRPSEEHVASRLTSPIVSTHLDTRNVAFERNKCGIWGWRSEKMETVSGYEAKVYSATNVELVTRTRTEHLSDQDKSRSKAGKTPFQSFLGMAQQHSSHTGAPVQQAASPTNPTAISPEEYFDPNFSLESRNIGRPIEMSSKVQRFKATLWLSEEHPLSLGDQVTPIIDLMAISNAHFAKLRDFITLRLPPGFPVKIEIPLFHVLNARITFSNLCGCDEPLSSVWVPAPSSAVAASGNPFPCEVDPTVFEVPNGYSVLGMERNEPLRDEDDDLLQFAIQQSLLEAGTEAEQVTVWEALTNTRPGARPPPQATVYEEQLQLERALQESLQLSTEPRGPGSPPRTPPAPGPPSFEEQLRLALELSSREQEERERRGQQEEEDLQRILQLSLTEH
Domains
DOMAIN 395 414 UIM 1 DOMAIN 441 460 UIM 2 DOMAIN 477 496 UIM 3 DOMAIN 502 518 UIM 4
UIM sequence regions
395 - 414 DDLLQFAIQQSLLEAGTEAE 441 - 460 QLQLERALQESLQLSTEPRG 477 - 496 EEQLRLALELSSREQEERER 502 - 518 EEDLQRILQLSLTEH
Function
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane