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Q7L273 Proteins Pentapeptide repeat domain Repeats
Uniprot ID:Q7L273
Protein name: BTB/POZ domain-containing protein KCTD9
Gene : KCTD9
Protein Family:
Squence Length : 389
Sequnce
>Q7L273 390 MRRVTLFLNGSPKNGKVVAVYGTLSDLLSVASSKLGIKATSVYNGKGGLIDDIALIRDDDVLFVCEGEPFIDPQTDSKPPEGLLGFHTDWLTLNVGGRYFTTTRSTLVNKEPDSMLAHMFKDKGVWGNKQDHRGAFLIDRSPEYFEPILNYLRHGQLIVNDGINLLGVLEEARFFGIDSLIEHLEVAIKNSQPPEDHSPISRKEFVRFLLATPTKSELRCQGLNFSGADLSRLDLRYINFKMANLSRCNLAHANLCCANLERADLSGSVLDCANLQGVKMLCSNAEGASLKLCNFEDPSGLKANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLENCDLSGCDLQEANLRGSNVKGAIFEEMLTPLHMSQSVR
Domains
DOMAIN 3 82 KHA DOMAIN 89 161 BTB DOMAIN 224 256 Pentapeptide repeat 1 DOMAIN 258 297 Pentapeptide repeat 2 DOMAIN 338 376 Pentapeptide repeat 3
Pentapeptide repeat sequence regions
224 - 256 SGADLSRLDLRYINFKMANLSRCNLAHANLCCA 258 - 297 LERADLSGSVLDCANLQGVKMLCSNAEGASLKLCNFEDPS 338 - 376 LRGATLAGTDLENCDLSGCDLQEANLRGSNVKGAIFEEM
Function
"Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome"
Mutation
125 125 V->A: Impaired interaction with CUL3