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Q86T82 Proteins UIM domain Repeats

Uniprot ID:Q86T82	Protein name: Ubiquitin carboxyl-terminal hydrolase 37	Gene : USP37 KIAA1594
Protein Family:Peptidase C19 family	Squence Length : 979

Sequnce	>Q86T82 980 MSPLKIHGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLPAAMKPSQGSGSFGAILGSRTSQKETSRQLSYSDNQASAKRGSLETKDDIPFRKVLGNPGRGSIKTVAGSGIARTIPSLTSTSTPLRSGLLENRTEKRKRMISTGSELNEDYPKENDSSSNNKAMTDPSRKYLTSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDRTNVSSQTPSAKRSLGFLPQPVPLSVKKLRCNQDYTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVSGEENSPDISATRAYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEKCGGKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKPPFTLGWSAHMAISRPLKASQMVNSCITSPSTPSKKFTFKSKSSLALCLDSDSEDELKRSVALSQRLCEMLGNEQQQEDLEKDSKLCPIEPDKSELENSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSSPDTGFAEDDIQEMPENPDTMETEKPKTITELDPASFTEITKDCDENKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELSLQEFNNSFVDALGSDEDSGNEDVFDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEIFDELLETEKNSQSLSTEVGKTTRQAL
Domains	DOMAIN 341 951 USP DOMAIN 704 723 UIM 1 DOMAIN 806 825 UIM 2 DOMAIN 828 847 UIM 3
UIM sequence regions	704 - 723 EELLAAVLEISKRDASPSLS 806 - 825 EQELQQALAQSLQEQEAWEQ 828 - 847 DDDLKRATELSLQEFNNSFV
Function	"Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872)"
Active Site	ACT_SITE 350 350 Nucleophile. ACT_SITE 906 906 Proton acceptor
Motifs	MOTIF 32 34 KEN box 1. MOTIF 71 79 D-box 1. MOTIF 96 105 D-box 2. MOTIF 160 168 D-box 3. MOTIF 221 223 KEN box 2. MOTIF 782 784 KEN box 3
Mutation	"32 34 KEN->AAA: No effect 71 74 RLML->ALMA: No effect 96 99 RLFL->ALFA: No effect 160 163 RKVL->AKVA: No effect 221 223 KEN->AAA: No effect 350 350 C->S: Abolishes deubiquitinase activity 628 628 S->A: Abolishes phosphorylation by CDK2, leading to lower deubiquitinase activity 782 784 KEN->AAA: Impaired interaction with FZR1/CDH1 and subsequent ubiquitination"