HOME
BACK
Q8IX30 Proteins EGF-like domain Repeats
Uniprot ID:Q8IX30
Protein name: "Signal peptide, CUB and EGF-like domain-containing protein 3"
Gene : SCUBE3 CEGF3
Protein Family:
Squence Length : 993
Sequnce
>Q8IX30 994 MGSGRVPGLCLLVLLVHARAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAVLSIKQRASFKIKDAKCRLHLRNKGKTEEAGRITGPGGAPCSECQVTFIHLKCDSSRKGKGRRARTPPGKEVTRLTLELEAEVRAEETTASCGLPCLRQRMERRLKGSLKMLRKSINQDRFLLRLAGLDYELAHKPGLVAGERAEPMESCRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAMGSYQPDFRQNFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYPAGVECIWNINPPPKRKILIVVPEIFLPSEDECGDVLVMRKNSSPSSITTYETCQTYERPIAFTARSRKLWINFKTSEANSARGFQIPYVTYDEDYEQLVEDIVRDGRLYASENHQEILKDKKLIKAFFEVLAHPQNYFKYTEKHKEMLPKSFIKLLRSKVSSFLRPYK
Domains
DOMAIN 29 69 EGF-like 1 calcium-binding DOMAIN 70 111 EGF-like 2 calcium-binding DOMAIN 112 148 EGF-like 3 calcium-binding DOMAIN 157 198 EGF-like 4 DOMAIN 199 237 EGF-like 5 DOMAIN 238 276 EGF-like 6 DOMAIN 277 317 EGF-like 7 calcium-binding DOMAIN 318 356 EGF-like 8 calcium-binding DOMAIN 357 398 EGF-like 9 calcium-binding DOMAIN 804 916 CUB
EGF-like sequence regions
29 - 69 DECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDV 70 - 111 DECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDV 112 - 148 DECAEGNGGCQQSCVNMMGSYECHCREGFFLSDNQHT 157 - 198 MNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT 199 - 237 CNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIET 238 - 276 CAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDI 277 - 317 DECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDI 318 - 356 DECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDV 357 - 398 DECSINRGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEP
Function
"Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression"