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Q8IZ07 Proteins UIM domain Repeats
Uniprot ID:Q8IZ07
Protein name: Ankyrin repeat domain-containing protein 13A
Gene : ANKRD13A ANKRD13
Protein Family:
Squence Length : 590
Sequnce
>Q8IZ07 591 MSSACDAGDHYPLHLLVWKNDYRQLEKELQGQNVEAVDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENRQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLQKILEAPDFYVQMKWEFTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKGEDNWAELMEVNHDDKVVTTERFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNIAFERTKSGFWGWRTDKAEVVNGYEAKVYTVNNVNVITKIRTEHLTEEEKKRYKADRNPLESLLGTVEHQFGAQGDLTTECATANNPTAITPDEYFNEEFDLKDRDIGRPKELTIRTQKFKAMLWMCEEFPLSLVEQVIPIIDLMARTSAHFARLRDFIKLEFPPGFPVKIEIPLFHVLNARITFGNVNGCSTAEESVSQNVEGTQADSASHITNFEVDQSVFEIPESYYVQDNGRNVHLQDEDYEIMQFAIQQSLLESSRSQELSGPASNGGISQTNTYDAQYERAIQESLLTSTEGLCPSALSETSRFDNDLQLAMELSAKELEEWELRLQEEEAELQQVLQLSLTDK
Domains
DOMAIN 483 502 UIM 1 DOMAIN 519 538 UIM 2 DOMAIN 549 568 UIM 3 DOMAIN 574 590 UIM 4
UIM sequence regions
483 - 502 YEIMQFAIQQSLLESSRSQE 519 - 538 DAQYERAIQESLLTSTEGLC 549 - 568 DNDLQLAMELSAKELEEWEL 574 - 590 EAELQQVLQLSLTDK
Function
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane
Mutation
"491 495 AIQQS->GIQQA: No effect on 'Lys-63'-linked ubiquitin binding and interaction with EGFR when associated with 527-G--A-531 when associated with 527-G--A-531 and 557-G--A-561 when associated with 527-G--A-531, 557-G--A-561 and 582-G--A-586 527 531 AIQES->GIQEA: No effect on 'Lys-63'-linked ubiquitin binding and interaction with EGFR when associated with 491-G--A-495 when associated with 557-G--A-561 when associated with 491-G--A-495 and 557-G--A-561 when associated with 557-G--A-561 and 582-G--A-586 when associated with 491-G--A-495, 557-G--A-561 and 582-G--A-586 557 561 AMELS->GMELA: Slightly inhibits 'Lys-63'-linked ubiquitin binding and strongly inhibits interaction with EGFR when associated with 527-G--A-531 when associated with 491-G--A-495 and 527-G--A-531 when associated with 582-V--S-586 when associated with 491-G--A-495, 527-G--A-531 and 582-G--A-586 582 586 VLQLS->GLQLA: Abolishes 'Lys-63'-linked ubiquitin binding and strongly inhibits interaction with EGFR when associated with 557-G--A-561 when associated with 527-G--A-531 and 557-G--A-561 when associated with 491-G--A-495, 527-G--A-531 and 557-G--A-561"