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Q8N556 Proteins PH domain Repeats

Uniprot ID:Q8N556	Protein name: Actin filament-associated protein 1	Gene : AFAP1 AFAP
Protein Family:	Squence Length : 730

Sequnce	>Q8N556 731 MEELIVELRLFLELLDHEYLTSTVREKKAVITNILLRIQSSKGFDVKDHAQKQETANSLPAPPQMPLPEIPQPWLPPDSGPPPLPTSSLPEGYYEEAVPLSPGKAPEYITSNYDSDAMSSSYESYDEEEEDGKGKKTRHQWPSEEASMDLVKDAKICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGCSGPVDSECPPPPSSPVHKAELEKKLSSERPSSDGEGVVENGITTCNGKEQVKRKKSSKSEAKGTVSKVTGKKITKIISLGKKKPSTDEQTSSAEEDVPTCGYLNVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSSTDPEALHYDYIDVEMSASVIQTAKQTFCFMNRRVISANPYLGGTSNGYAHPSGTALHYDDVPCINGSLKGKKPPVASNGVTGKGKTLSSQPKKADPAAVVKRTGSNAAQYKYGKNRVEADAKRLQTKEEELLKRKEALRNRLAQLRKERKDLRAAIEVNAGRKPQAILEEKLKQLEEECRQKEAERVSLELELTEVKESLKKALAGGVTLGLAIEPKSGTSSPQSPVFRHRTLENSPISSCDTSDTEGPVPVNSAAVLKKSQAAPGSSPCRGHVLRKAKEWELKNGT
Domains	DOMAIN 153 249 PH 1 DOMAIN 347 441 PH 2
PH sequence regions	153 - 249 KICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQPQMELPLQGCNITYIPKDSKKKKHELKITQQGTDPLVLAVQSKEQAEQWLKVIKEAYSGC 347 - 441 PTCGYLNVLSNSRWRERWCRVKDNKLIFHKDRTDLKTHIVSIPLRGCEVIPGLDSKHPLTFRLLRNGQEVAVLEASSSEDMGRWIGILLAETGSS
Function	"Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells"
Motifs	MOTIF 71 74 SH3-binding. MOTIF 94 97 SH2-binding 1. MOTIF 451 456 SH2-binding 2
Mutation	71 71 P->A: Decreased tyrosine phosphorylation 77 77 P->A: No effect on tyrosine phosphorylation 93 93 Y->F: Reduces phosphorylation and phosphorylation of SRC at Y-416 when associated with F-94 F-125 F-451 and F-453 94 94 Y->F: Reduces phosphorylation and phosphorylation of SRC at Y-416 when associated with F-93 F-125 F-451 and F-453 125 125 Y->F: Reduces phosphorylation and phosphorylation of SRC at Y-416 when associated with F-93 F-94 F-451 and F-453 451 451 Y->F: Reduces phosphorylation and phosphorylation of SRC at Y-416 when associated with F-93 F-94 F-125 and F-453 453 453 Y->F: Reduces phosphorylation and phosphorylation of SRC at Y-416 when associated with F-93 F-94 F-125 and F-451