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Q8NFA2 Proteins SH3 domain Repeats
Uniprot ID:Q8NFA2
Protein name: NADPH oxidase organizer 1
Gene : NOXO1 P41NOX SH3PXD5
Protein Family:
Squence Length : 376
Sequnce
>Q8NFA2 377 MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEAGLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQGRPRGCVDSVPHPTTEQ
Domains
DOMAIN 1 131 PX DOMAIN 163 225 SH3 1 DOMAIN 237 296 SH3 2
SH3 sequence regions
163 - 225 AQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQ 237 - 296 GPQFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGA
Function
"Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity"
Mutation
40 40 R->Q: Loss of ability to activate NOX1 associated with loss of lipid-binding and plasma membrane localization 202 202 W->R: Loss of ability to activate NOX3 and interact with CYBA 274 274 W->R: Induces interaction with NOXA1 in vitro 332 332 P->A: Loss of intramolecular interaction 334 334 R->A: Loss of intramolecular interaction