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Q8WWQ8 Proteins EGF-like domain Repeats
Uniprot ID:Q8WWQ8
Protein name: Stabilin-2
Gene : STAB2 FEEL2 FELL FEX2 HARE
Protein Family:
Squence Length : 2551
Sequnce
>Q8WWQ8 2552 MMLQHLVIFCLGLVVQNFCSPAETTGQARRCDRKSLLTIRTECRSCALNLGVKCPDGYTMITSGSVGVRDCRYTFEVRTYSLSLPGCRHICRKDYLQPRCCPGRWGPDCIECPGGAGSPCNGRGSCAEGMEGNGTCSCQEGFGGTACETCADDNLFGPSCSSVCNCVHGVCNSGLDGDGTCECYSAYTGPKCDKPIPECAALLCPENSRCSPSTEDENKLECKCLPNYRGDGKYCDPINPCLRKICHPHAHCTYLGPNRHSCTCQEGYRGDGQVCLPVDPCQINFGNCPTKSTVCKYDGPGQSHCECKEHYQNFVPGVGCSMTDICKSDNPCHRNANCTTVAPGRTECICQKGYVGDGLTCYGNIMERLRELNTEPRGKWQGRLTSFISLLDKAYAWPLSKLGPFTVLLPTDKGLKGFNVNELLVDNKAAQYFVKLHIIAGQMNIEYMNNTDMFYTLTGKSGEIFNSDKDNQIKLKLHGGKKKVKIIQGDIIASNGLLHILDRAMDKLEPTFESNNEQTIMTMLQPRYSKFRSLLEETNLGHALDEDGVGGPYTIFVPNNEALNNMKDGTLDYLLSPEGSRKLLELVRYHIVPFTQLEVATLISTPHIRSMANQLIQFNTTDNGQILANDVAMEEIEITAKNGRIYTLTGVLIPPSIVPILPHRCDETKREMKLGTCVSCSLVYWSRCPANSEPTALFTHRCVYSGRFGSLKSGCARYCNATVKIPKCCKGFYGPDCNQCPGGFSNPCSGNGQCADSLGGNGTCICEEGFQGSQCQFCSDPNKYGPRCNKKCLCVHGTCNNRIDSDGACLTGTCRDGSAGRLCDKQTSACGPYVQFCHIHATCEYSNGTASCICKAGYEGDGTLCSEMDPCTGLTPGGCSRNAECIKTGTGTHTCVCQQGWTGNGRDCSEINNCLLPSAGGCHDNASCLYVGPGQNECECKKGFRGNGIDCEPITSCLEQTGKCHPLASCQSTSSGVWSCVCQEGYEGDGFLCYGNAAVELSFLSEAAIFNRWINNASLQPTLSATSNLTVLVPSQQATEDMDQDEKSFWLSQSNIPALIKYHMLLGTYRVADLQTLSSSDMLATSLQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVPQRRLTGSLPNLLMRLEQMPDYSIFRGYIIQYNLANAIEAADAYTVFAPNNNAIENYIREKKVLSLEEDVLRYHVVLEEKLLKNDLHNGMHRETMLGFSYFLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVLEIQKNRCDNNDTTIIRGRCRTCSSELTCPFGTKSLGNEKRRCIYTSYFMGRRTLFIGCQPKCVRTVITRECCAGFFGPQCQPCPGNAQNVCFGNGICLDGVNGTGVCECGEGFSGTACETCTEGKYGIHCDQACSCVHGRCNQGPLGDGSCDCDVGWRGVHCDNATTEDNCNGTCHTSANCLTNSDGTASCKCAAGFQGNGTICTAINACEISNGGCSAKADCKRTTPGRRVCTCKAGYTGDGIVCLEINPCLENHGGCDKNAECTQTGPNQAACNCLPAYTGDGKVCTLINVCLTKNGGCSEFAICNHTGQVERTCTCKPNYIGDGFTCRGSIYQELPKNPKTSQYFFQLQEHFVKDLVGPGPFTVFAPLSAAFDEEARVKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVISVSQSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPFKRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCYRMKDVNCTCKVGYVGDGFSCSGNLLQVLMSFPSLTNFLTEVLAYSNSSARGRAFLEHLTDLSIRGTLFVPQNSGLGENETLSGRDIEHHLANVSMFFYNDLVNGTTLQTRLGSKLLITASQDPLQPTETRFVDGRAILQWDIFASNGIIHVISRPLKAPPAPVTLTHTGLGAGIFFAIILVTGAVALAAYSYFRINRRTIGFQHFESEEDINVAALGKQQPENISNPLYESTTSAPPEPSYDPFTDSEERQLEGNDPLRTL
Domains
DOMAIN 108 148 EGF-like 1 DOMAIN 156 193 EGF-like 2 DOMAIN 195 236 EGF-like 3 DOMAIN 237 276 EGF-like 4 DOMAIN 322 362 EGF-like 5 DOMAIN 371 505 FAS1 1 DOMAIN 515 652 FAS1 2 DOMAIN 736 776 EGF-like 6 DOMAIN 826 866 EGF-like 7 DOMAIN 867 909 EGF-like 8 DOMAIN 910 952 EGF-like 9 DOMAIN 953 992 EGF-like 10 DOMAIN 994 1127 FAS1 3 DOMAIN 1137 1265 FAS1 4 DOMAIN 1343 1408 Laminin EGF-like 1 DOMAIN 1432 1470 EGF-like 11 DOMAIN 1471 1512 EGF-like 12 DOMAIN 1513 1554 EGF-like 13 DOMAIN 1555 1594 EGF-like 14 DOMAIN 1596 1724 FAS1 5 DOMAIN 1740 1881 FAS1 6 DOMAIN 1957 2022 Laminin EGF-like 2 DOMAIN 2047 2081 EGF-like 15 DOMAIN 2082 2122 EGF-like 16 DOMAIN 2123 2165 EGF-like 17 DOMAIN 2198 2291 Link DOMAIN 2311 2446 FAS1 7
EGF-like sequence regions
108 - 148 IECPGGAGSPCNGRGSCAEGMEGNGTCSCQEGFGGTACETC 156 - 193 PSCSSVCNCVHGVCNSGLDGDGTCECYSAYTGPKCDKP 195 - 236 PECAALLCPENSRCSPSTEDENKLECKCLPNYRGDGKYCDPI 237 - 276 NPCLRKICHPHAHCTYLGPNRHSCTCQEGYRGDGQVCLPV 322 - 362 DICKSDNPCHRNANCTTVAPGRTECICQKGYVGDGLTCYGN 736 - 776 NQCPGGFSNPCSGNGQCADSLGGNGTCICEEGFQGSQCQFC 826 - 866 SACGPYVQFCHIHATCEYSNGTASCICKAGYEGDGTLCSEM 867 - 909 DPCTGLTPGGCSRNAECIKTGTGTHTCVCQQGWTGNGRDCSEI 910 - 952 NNCLLPSAGGCHDNASCLYVGPGQNECECKKGFRGNGIDCEPI 953 - 992 TSCLEQTGKCHPLASCQSTSSGVWSCVCQEGYEGDGFLCY 1343 - 1408 CQPCPGNAQNVCFGNGICLDGVNGTGVCECGEGFSGTACETCTEGKYGIHCDQACSCVHGRCNQGP 1432 - 1470 DNCNGTCHTSANCLTNSDGTASCKCAAGFQGNGTICTAI 1471 - 1512 NACEISNGGCSAKADCKRTTPGRRVCTCKAGYTGDGIVCLEI 1513 - 1554 NPCLENHGGCDKNAECTQTGPNQAACNCLPAYTGDGKVCTLI 1555 - 1594 NVCLTKNGGCSEFAICNHTGQVERTCTCKPNYIGDGFTCR 1957 - 2022 CQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGI 2047 - 2081 AVCTPPCSAHATCKENNTCECNLDYEGDGITCTVV 2082 - 2122 DFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEI 2123 - 2165 DPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPE
Function
"Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS"