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Q8WXF1 Proteins RRM domain Repeats
Uniprot ID:Q8WXF1
Protein name: Paraspeckle component 1
Gene : PSPC1 PSP1
Protein Family:PSPC family
Squence Length : 523
Sequnce
>Q8WXF1 524 MMLRGNLKQVRIEKNPARLRALESAVGESEPAAAAAMALALAGEPAPPAPAPPEDHPDEEMGFTIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEKLMQKTQQYHKEREQPPRFAQPGTFEFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLMRQDLMRRQEELRRLEELRNQELQKRKQIQLRHEEEHRRREEEMIRHREQEELRRQQEGFKPNYMENREQEMRMGDMGPRGAINMGDAFSPAPAGNQGPPPMMGMNMNNRATIPGPPMGPGPAMGPEGAANMGTPMMPDNGAVHNDRFPQGPPSQMGSPMGSRTGSETPQAPMSGVGPVSGGPGGFGRGSQGGNFEGPNKRRRY
Domains
DOMAIN 82 154 RRM 1 DOMAIN 156 237 RRM 2
RRM sequence regions
82 - 154 LFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTILKSRPLRIRFATHGA 156 - 237 LTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFD
Function
"Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway"
Mutation
"119 119 F->A: Abolishes accumulation in paraspeckles, but not in perinucleolar caps when associated with A-121 A-198 and A-200 121 121 F->A: Abolishes accumulation in paraspeckles, but not in perinucleolar caps when associated with A-119 A-198 and A-200 198 198 K->A: Abolishes accumulation in paraspeckles, but not in perinucleolar caps when associated with A-119 A-121 and A-200 200 200 F->A: Abolishes accumulation in paraspeckles, but not in perinucleolar caps when associated with A-119 A-121 and A-198 275 275 Y->A: Abolishes interaction with NONO and localization in nuclear paraspeckles when associated with A-279 279 279 W->A: Abolishes interaction with NONO and localization in nuclear paraspeckles when associated with A-275"