Uniprot ID:Q92673	Protein name: Sortilin-related receptor	Gene : SORL1 C11orf32
Protein Family:"VPS10-related sortilin family, SORL1 subfamily"	Squence Length : 2214

Sequnce	>Q92673 2215 MATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRLWARGDARGASRADEKPLRRKRSAALQPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKQENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKTNTVLKVLKPDTTYQVKVQVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSLPREAEGVIVGHWAPPIHTHGLIREYIVEYSRSGSKMWASQRAASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSITTIKGKVIPPPDIHIDSYGENYLSFTLTMESDIKVNGYVVNLFWAFDTHKQERRTLNFRGSILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLKAKAINQTAVECTWTGPRNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVRVVVPYQGPSSDYVVVKMIPDSRLPPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAVAVKDLIRKTDRSYKVKSRNSTVEYTLNKLEPGGKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKHFNESRGYEIHMFDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQARCLFGNQICGEPAILLYDELGSGADASATQAARSTDVAAVVVPILFLILLSLGVGFAILYTKHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA
Domains	DOMAIN 1026 1072 EGF-like DOMAIN 1076 1114 LDL-receptor class A 1 DOMAIN 1115 1155 LDL-receptor class A 2 DOMAIN 1156 1194 LDL-receptor class A 3 DOMAIN 1198 1236 LDL-receptor class A 4 DOMAIN 1238 1272 LDL-receptor class A 5 DOMAIN 1273 1317 LDL-receptor class A 6 DOMAIN 1323 1361 LDL-receptor class A 7 DOMAIN 1366 1405 LDL-receptor class A 8 DOMAIN 1417 1455 LDL-receptor class A 9 DOMAIN 1469 1508 LDL-receptor class A 10 DOMAIN 1512 1551 LDL-receptor class A 11 DOMAIN 1557 1649 Fibronectin type-III 1 DOMAIN 1653 1745 Fibronectin type-III 2 DOMAIN 1749 1844 Fibronectin type-III 3 DOMAIN 1843 1927 Fibronectin type-III 4 DOMAIN 1934 2029 Fibronectin type-III 5 DOMAIN 2030 2118 Fibronectin type-III 6
LDL-receptor class A sequence regions	1076 - 1114 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTI 1115 - 1155 CDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQ 1156 - 1194 CRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIY 1198 - 1236 EASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKK 1238 - 1272 NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPL 1273 - 1317 CTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDP 1323 - 1361 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPT 1366 - 1405 CSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSH 1417 - 1455 CLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLA 1469 - 1508 CDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHS 1512 - 1551 CMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDEL
Function	"Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization"
Motifs	MOTIF 63 65 Cell attachment site. MOTIF 2172 2177 Endocytosis signal
Disease	"DISEASE: Alzheimer disease (AD) [MIM:104300]: Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits The major constituents of these plaques are neurotoxic amyloid-beta protein 40 and amyloid-beta protein 42, that are produced by the proteolysis of the transmembrane APP protein The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products, such as C31, are also implicated in neuronal death Note=The gene represented in this entry is involved in disease pathogenesis"

Q92673 Proteins LDL-receptor class A domain Repeats