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Q93052 Proteins LIM zinc-binding domain Repeats
Uniprot ID:Q93052
Protein name: Lipoma-preferred partner
Gene : LPP
Protein Family:Zyxin/ajuba family
Squence Length : 612
Sequnce
>Q93052 613 MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL
Domains
DOMAIN 414 473 LIM zinc-binding 1 DOMAIN 474 534 LIM zinc-binding 2 DOMAIN 535 603 LIM zinc-binding 3
LIM zinc-binding sequence regions
414 - 473 CARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQ 474 - 534 CNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRC 535 - 603 SVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLT
Function
"May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.2}"
Mutation
610 610 T->A: Abolishes binding to SCRIB 612 612 L->A: Abolishes binding to SCRIB
Disease
DISEASE: Note=A chromosomal aberration involving LPP is associated with a subclass of benign mesenchymal tumors known as lipomas Translocation t(3;12)(q27-q28;q13-q15) with HMGA2 is shown in lipomas ; DISEASE: Note=A chromosomal aberration involving LPP is associated with pulmonary chondroid hamartomas Translocation t(3;12)(q27-q28;q14-q15) with HMGA2 is detected in pulmonary chondroid hamartomas ; DISEASE: Note=A chromosomal aberration involving LPP is associated with parosteal lipomas Translocation t(3;12)(q28;q14) with HMGA2 is also shown in one parosteal lipoma ; DISEASE: Note=A chromosomal aberration involving LPP is associated with acute monoblastic leukemia Translocation t(3;11)(q28;q23) with KMT2A/MLL1 is associated with acute monoblastic leukemia