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Q969G2 Proteins LIM zinc-binding domain Repeats
Uniprot ID:Q969G2
Protein name: LIM/homeobox protein Lhx4
Gene : LHX4
Protein Family:
Squence Length : 390
Sequnce
>Q969G2 391 MMQSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF
Domains
DOMAIN 28 87 LIM zinc-binding 1 DOMAIN 88 150 LIM zinc-binding 2
LIM zinc-binding sequence regions
28 - 87 CAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKC 88 - 150 TACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDD
Function
May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (PubMed:28473536)
Disease
"DISEASE: Pituitary hormone deficiency, combined, 4 (CPHD4) [MIM:262700]: Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones CPHD4 is characterized by complete or partial deficiencies of growth hormone, thyroid-stimulating hormone, luteinizing hormone, follicle stimulating hormone and adrenocorticotropic hormone Clinical features include short stature, cerebellar defects, and small sella turcica Note=The disease is caused by mutations affecting the gene represented in this entry ; DISEASE: Note=A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia Translocation t(1;14)(q25;q32) with IGHG1"