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Q96QV1 Proteins EGF-like domain Repeats

Uniprot ID:Q96QV1	Protein name: Hedgehog-interacting protein	Gene : HHIP HIP UNQ5825/PRO19644
Protein Family:HHIP family	Squence Length : 700

Sequnce	>Q96QV1 701 MLKMLSFKLLLLAVALGFFEGDAKFGERNEGSGARRRRCLNGNPPKRLKRRDRRMMSQLELLSGGEMLCGGFYPRLSCCLRSDSPGLGRLENKIFSVTNNTECGKLLEEIKCALCSPHSQSLFHSPEREVLERDLVLPLLCKDYCKEFFYTCRGHIPGFLQTTADEFCFYYARKDGGLCFPDFPRKQVRGPASNYLDQMEEYDKVEEISRKHKHNCFCIQEVVSGLRQPVGALHSGDGSQRLFILEKEGYVKILTPEGEIFKEPYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKLYVSYTTNQERWAIGPHDHILRVVEYTVSRKNPHQVDLRTARVFLEVAELHRKHLGGQLLFGPDGFLYIILGDGMITLDDMEEMDGLSDFTGSVLRLDVDTDMCNVPYSIPRSNPHFNSTNQPPEVFAHGLHDPGRCAVDRHPTDININLTILCSDSNGKNRSSARILQIIKGKDYESEPSLLEFKPFSNGPLVGGFVYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTKQWQEKPLCLGTSGSCRGYFSGHILGFGEDELGEVYILSSSKSMTQTHNGKLYKIVDPKRPLMPEECRATVQPAQTLTSECSRLCRNGYCTPTGKCCCSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQVDRNIRRVTRAGILDQIIDMTSYLLDLTSYIV
Domains	DOMAIN 607 634 EGF-like 1 DOMAIN 635 667 EGF-like 2
EGF-like sequence regions	607 - 634 SRLCRNGYCTPTGKCCCSPGWEGDFCRT 635 - 667 AKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQV
Function	Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family
Mutation	"380 380 E->A: Abolishes SHH binding 382 382 M->A: Abolishes SHH binding 383 383 D->A,R: Abolishes SHH binding 387 387 D->A: Abolishes SHH binding"