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Q99435 Proteins EGF-like domain Repeats
Uniprot ID:Q99435
Protein name: Protein kinase C-binding protein NELL2
Gene : NELL2 NRP2
Protein Family:
Squence Length : 816
Sequnce
>Q99435 817 MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL
Domains
DOMAIN 64 228 Laminin G-like DOMAIN 272 331 VWFC 1 DOMAIN 397 439 EGF-like 1 DOMAIN 440 481 EGF-like 2 calcium-binding DOMAIN 482 522 EGF-like 3 calcium-binding DOMAIN 523 553 EGF-like 4 DOMAIN 555 601 EGF-like 5 calcium-binding DOMAIN 602 637 EGF-like 6 calcium-binding DOMAIN 638 693 VWFC 2 DOMAIN 698 756 VWFC 3
EGF-like sequence regions
397 - 439 DFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDI 440 - 481 DECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEH 482 - 522 DECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAF 523 - 553 CKDGCRNGGACIAANVCACPQGFTGPSCETD 555 - 601 DECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDI 602 - 637 DECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGD
Function
Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity)