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Q99466 Proteins EGF-like domain Repeats
Uniprot ID:Q99466
Protein name: Neurogenic locus notch homolog protein 4
Gene : NOTCH4 INT3
Protein Family:NOTCH family
Squence Length : 2003
Sequnce
>Q99466 2004 MQPPSLLLLLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRPEDGDPEWGPSLALLVVLSPPALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPGARAEEKLGGTRDPTYQERAAPQTQPLGKETDSLSAGFVVVMGVDLSRCGPDHPASRCPWDPGLLLRFLAAMAAVGALEPLLPGPLLAVHPHAGTAPPANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQSAPHRRRPPLGEDSIGLKALKPKAEVDEDGVVMCSGPEEGEEVGQAEETGPPSTCQLWSLSGGCGALPQAAMLTPPQESEMEAPDLDTRGPDGVTPLMSAVCCGEVQSGTFQGAWLGCPEPWEPLLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGPPEARHKATPGREAGPFPRARTVSVSVPPHGGGALPRCRTLSAGAGPRGGGACLQARTWSVDLAARGGGAYSHCRSLSGVGAGGGPTPRGRRFSAGMRGPRPNPAIMRGRYGVAAGRGGRVSTDDWPCDWVALGACGSASNIPIPPPCLTPSPERGSPQLDCGPPALQEMPINQGGEGKK
Domains
DOMAIN 24 63 EGF-like 1 DOMAIN 64 115 EGF-like 2 DOMAIN 118 155 EGF-like 3 DOMAIN 156 192 EGF-like 4 DOMAIN 194 232 EGF-like 5 calcium-binding DOMAIN 234 274 EGF-like 6 DOMAIN 276 312 EGF-like 7 calcium-binding DOMAIN 314 353 EGF-like 8 calcium-binding DOMAIN 355 391 EGF-like 9 calcium-binding DOMAIN 392 430 EGF-like 10 DOMAIN 432 473 EGF-like 11 calcium-binding DOMAIN 475 511 EGF-like 12 calcium-binding DOMAIN 513 549 EGF-like 13 calcium-binding DOMAIN 551 587 EGF-like 14 calcium-binding DOMAIN 589 625 EGF-like 15 calcium-binding DOMAIN 626 659 EGF-like 16 DOMAIN 661 689 EGF-like 17 DOMAIN 691 727 EGF-like 18 DOMAIN 729 765 EGF-like 19 DOMAIN 767 803 EGF-like 20 DOMAIN 806 842 EGF-like 21 DOMAIN 844 880 EGF-like 22 DOMAIN 882 928 EGF-like 23 DOMAIN 930 966 EGF-like 24 DOMAIN 968 1004 EGF-like 25 DOMAIN 1006 1044 EGF-like 26 DOMAIN 1046 1085 EGF-like 27 DOMAIN 1087 1126 EGF-like 28 DOMAIN 1130 1171 EGF-like 29
EGF-like sequence regions
24 - 63 LLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFP 64 - 115 DPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAK 118 - 155 DPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLR 156 - 192 DFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERD 194 - 232 NECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELR 234 - 274 GPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVN 276 - 312 DNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSED 314 - 353 DECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEEN 355 - 391 DDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLE 392 - 430 DMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQD 432 - 473 DECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEAD 475 - 511 NECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVE 513 - 549 NECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEED 551 - 587 DECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTE 589 - 625 DECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVP 626 - 659 LCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPP 661 - 689 DNCTCHHGHCQRSSCVCDVGWTGPECEAE 691 - 727 GGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEE 729 - 765 TACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTS 767 - 803 DYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGK 806 - 842 PSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTL 844 - 880 DLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLP 882 - 928 SSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDH 930 - 966 NPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKE 968 - 1004 DACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGD 1006 - 1044 DECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVE 1046 - 1085 DPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHR 1087 - 1126 PSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTP 1130 - 1171 KGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKP
Function
"Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity)"