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Q9HB21 Proteins PH domain Repeats
Uniprot ID:Q9HB21
Protein name: Pleckstrin homology domain-containing family A member 1
Gene : PLEKHA1 TAPP1
Protein Family:
Squence Length : 404
Sequnce
>Q9HB21 405 MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLPYFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASSEHPPGPSESKHAFRPTNAATATSHSTASRSNSLVSTFTMEKRGFYESLAKVKPGNFKVQTVSPREPASKVTEQALLRPQSKNGPQEKDCDLVDLDDASLPVSDV
Domains
DOMAIN 7 112 PH 1 DOMAIN 191 289 PH 2
PH sequence regions
7 - 112 RICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKIT 191 - 289 IKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQ
Function
"Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane"
Mutation
"28 28 R->L: No effect on phosphatidylinositide binding 203 205 AVM->GGG: Abolishes phosphatidylinositide binding 203 205 AVM->GLV: Binds both PtdIns3,4P2 and PtdIns3,4,5P3 203 204 AV->GG: Binds both PtdIns3,4P2 and PtdIns3,4,5P3 203 203 A->G: Binds both PtdIns3,4P2 and PtdIns3,4,5P3 204 204 V->L: No effect 205 205 M->V: No effect 207 207 N->T: No effect 211 211 R->L: Abolishes phosphatidylinositide binding"