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Q9HCE7 Proteins WW domain Repeats
Uniprot ID:Q9HCE7
Protein name: E3 ubiquitin-protein ligase SMURF1
Gene : SMURF1 KIAA1625
Protein Family:
Squence Length : 757
Sequnce
>Q9HCE7 758 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
Domains
DOMAIN 1 99 C2 DOMAIN 234 267 WW 1 DOMAIN 306 339 WW 2 DOMAIN 420 757 HECT
WW sequence regions
234 - 267 LPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPS 306 - 339 LPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHH
Function
"E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003)"
Active Site
ACT_SITE 725 725 Glycyl thioester intermediate
Mutation
"28 28 K->A: Fails to ubiquitinate RHOA when associated with A-85 85 85 K->A: Fails to ubiquitinate RHOA when associated with A-28 350 350 K->R: Abolishes FBXL15-mediated ubiquitination and degradation when associated with R-381 and R-381 381 381 K->R: Abolishes FBXL15-mediated ubiquitination and degradation when associated with R-350 and R-383 when associated with R-383 383 383 K->R: Abolishes FBXL15-mediated ubiquitination and degradation when associated with R-350 and R-381 when associated with R-381 725 725 C->A: Loss of enzyme activity, without abolishing FBXL15-mediated ubiquitination"