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Q9NQ36 Proteins EGF-like domain Repeats
Uniprot ID:Q9NQ36
Protein name: "Signal peptide, CUB and EGF-like domain-containing protein 2 "
Gene : SCUBE2 CEGP1
Protein Family:
Squence Length : 999
Sequnce
>Q9NQ36 1000 MGVAGRNRPGAAWAVLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDVDECSLDRTCDHSCINHPGTFACACNRGYTLYGFTHCGDTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSVSPRVSLHCGKSGGGDGCFLRCHSGIHLSSDVTTIRTSVTFKLNEGKCSLKNAELFPEGLRPALPEKHSSVKESFRYVNLTCSSGKQVPGAPGRPSTPKEMFITVEFELETNQKEVTASCDLSCIVKRTEKRLRKAIRTLRKAVHREQFHLQLSGMNLDVAKKPPRTSERQAESCGVGQGHAENQCVSCRAGTYYDGARERCILCPNGTFQNEEGQMTCEPCPRPGNSGALKTPEAWNMSECGGLCQPGEYSADGFAPCHLCALGTFQPEAGRTSCFPCGGGLATKHQGATSFQDCETRVQCSPGHFYNTTTHRCIRCPVGTYQPEFGKNNCVSCPGNTTTDFDGSTNITQCKNRRCGGELGDFTGYIESPNYPGNYPANTECTWTINPPPKRRILIVVPEIFLPIEDDCGDYLVMRKTSSSNSVTTYETCQTYERPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVTYDEDYQELIEDIVRDGRLYASENHQEILKDKKLIKALFDVLAHPQNYFKYTAQESREMFPRSFIRLLRSKVSRFLRPYK
Domains
DOMAIN 45 85 EGF-like 1 calcium-binding DOMAIN 86 127 EGF-like 2 calcium-binding DOMAIN 128 168 EGF-like 3 calcium-binding DOMAIN 177 213 EGF-like 4 DOMAIN 217 252 EGF-like 5 DOMAIN 286 321 EGF-like 6 DOMAIN 323 363 EGF-like 7 calcium-binding DOMAIN 364 402 EGF-like 8 calcium-binding DOMAIN 403 443 EGF-like 9 calcium-binding DOMAIN 809 921 CUB
EGF-like sequence regions
45 - 85 DECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDI 86 - 127 DECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDV 128 - 168 DECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHR 177 - 213 NKDHGCSHICKEAPRGSVACECRPGFELAKNQRDCIL 217 - 252 HGNGGCQHSCDDTADGPECSCHPQYKMHTDGRSCLE 286 - 321 VNNGGCDRTCKDTSTGVHCSCPVGFTLQLDGKTCKD 323 - 363 DECQTRNGGCDHFCKNIVGSFDCGCKKGFKLLTDEKSCQDV 364 - 402 DECSLDRTCDHSCINHPGTFACACNRGYTLYGFTHCGDT 403 - 443 NECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEV
Function
"Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687)"