HOME
BACK
Q9NRR5 Proteins STI1 domain Repeats
Uniprot ID:Q9NRR5
Protein name: Ubiquilin-4
Gene : UBQLN4 C1orf6 CIP75 UBIN
Protein Family:
Squence Length : 601
Sequnce
>Q9NRR5 602 MAEPSGAETRPPIRVTVKTPKDKEEIVICDRASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGDTLNQHGIKDGLTVHLVIKTPQKAQDPAAATASSPSTPDPASAPSTTPASPATPAQPSTSGSASSDAGSGSRRSSGGGPSPGAGEGSPSATASILSGFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEMLSQIMENPLVQDMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSSLAGNSDSSSSQPLRTENREPLPNPWSPSPPTSQAPGSGGEGTGGSGTSQVHPTVSNPFGINAASLGSGMFNSPEMQALLQQISENPQLMQNVISAPYMRSMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQNPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGISRTPAPSAGSNAGSTPEAPTSSPATPATSSPTGASSAQQQLMQQMIQLLAGSGNSQVQTPEVRFQQQLEQLNSMGFINREANLQALIATGGDINAAIERLLGSQLS
Domains
DOMAIN 13 87 Ubiquitin-like DOMAIN 192 229 STI1 1 DOMAIN 230 261 STI1 2 DOMAIN 393 440 STI1 3 DOMAIN 444 476 STI1 4 DOMAIN 553 598 UBA
STI1 sequence regions
192 - 229 EMLSQIMENPLVQDMMSNPDLMRHMIMANPQMQQLMER 230 - 261 NPEISHMLNNPELMRQTMELARNPAMMQEMMR 393 - 440 QLMQNVISAPYMRSMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRL 444 - 476 VFLQQMQNPESLSILTNPRAMQALLQIQQGLQT
Function
Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (Ref. 6). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205)
Mutation
55 55 I->A: Loss of interaction with UBQLN1