Uniprot ID:Q9NZR2	Protein name: Low-density lipoprotein receptor-related protein 1B	Gene : LRP1B LRPDIT
Protein Family:LDLR family	Squence Length : 4599

Sequnce	>Q9NZR2 4600 MSEFLLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCACAHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVPLVLLVTLITTLVIGLVLCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEVDHDHNDGGLLDPGFMIDPTKARYIGGGPSAFKLPHTAPPIYLNSDLKGPLTAGPTNYSNPVYAKLYMDGQNCRNSLGSVDERKELLPKKIEIGIRETVA
Domains	DOMAIN 31 70 LDL-receptor class A 1 DOMAIN 76 114 LDL-receptor class A 2 DOMAIN 116 154 EGF-like 1 DOMAIN 155 194 EGF-like 2 calcium-binding DOMAIN 471 517 EGF-like 3 DOMAIN 794 834 EGF-like 4 DOMAIN 844 882 LDL-receptor class A 3 DOMAIN 885 923 LDL-receptor class A 4 DOMAIN 926 963 LDL-receptor class A 5 DOMAIN 966 1003 LDL-receptor class A 6 DOMAIN 1005 1043 LDL-receptor class A 7 DOMAIN 1052 1089 LDL-receptor class A 8 DOMAIN 1094 1132 LDL-receptor class A 9 DOMAIN 1135 1174 LDL-receptor class A 10 DOMAIN 1174 1213 EGF-like 5 DOMAIN 1214 1253 EGF-like 6 DOMAIN 1527 1570 EGF-like 7 DOMAIN 1834 1875 EGF-like 8 DOMAIN 2143 2183 EGF-like 9 DOMAIN 2464 2504 EGF-like 10 DOMAIN 2509 2548 LDL-receptor class A 11 DOMAIN 2551 2587 LDL-receptor class A 12 DOMAIN 2590 2626 LDL-receptor class A 13 DOMAIN 2629 2675 LDL-receptor class A 14 DOMAIN 2681 2717 LDL-receptor class A 15 DOMAIN 2719 2757 LDL-receptor class A 16 DOMAIN 2760 2800 LDL-receptor class A 17 DOMAIN 2804 2841 LDL-receptor class A 18 DOMAIN 2844 2885 LDL-receptor class A 19 DOMAIN 2890 2926 LDL-receptor class A 20 DOMAIN 2927 2967 EGF-like 11 DOMAIN 2968 3008 EGF-like 12 calcium-binding DOMAIN 3273 3314 EGF-like 13 DOMAIN 3316 3353 LDL-receptor class A 21 DOMAIN 3356 3392 LDL-receptor class A 22 DOMAIN 3395 3432 LDL-receptor class A 23 DOMAIN 3435 3472 LDL-receptor class A 24 DOMAIN 3475 3511 LDL-receptor class A 25 DOMAIN 3514 3550 LDL-receptor class A 26 DOMAIN 3552 3588 LDL-receptor class A 27 DOMAIN 3593 3629 LDL-receptor class A 28 DOMAIN 3631 3668 LDL-receptor class A 29 DOMAIN 3673 3711 LDL-receptor class A 30 DOMAIN 3714 3752 LDL-receptor class A 31 DOMAIN 3761 3797 LDL-receptor class A 32 DOMAIN 3801 3843 EGF-like 14 DOMAIN 3844 3881 EGF-like 15 DOMAIN 4171 4208 EGF-like 16 DOMAIN 4213 4249 EGF-like 17 DOMAIN 4249 4285 EGF-like 18 DOMAIN 4285 4321 EGF-like 19 DOMAIN 4321 4357 EGF-like 20 DOMAIN 4357 4392 EGF-like 21 DOMAIN 4390 4427 EGF-like 22
EGF-like sequence regions	116 - 154 SNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQ 155 - 194 DECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAK 471 - 517 HACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRP 794 - 834 NMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFN 1174 - 1213 CSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIV 1214 - 1253 DYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSV 1527 - 1570 NPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEM 1834 - 1875 NSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGI 2143 - 2183 NVCARDNGGCKQLCLYRGNSRRTCACAHGYLAEDGVTCLRH 2464 - 2504 SPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTK 2927 - 2967 ECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDI 2968 - 3008 DECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSL 3273 - 3314 HLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCLSN 3801 - 3843 YTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDL 3844 - 3881 NECLVFGTCSHQCINVEGSYKCVCDQNFQERNNTCIAE 4171 - 4208 PNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDD 4213 - 4249 DSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVN 4249 - 4285 NHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKT 4285 - 4321 TVCEDFCQNGGTCIVTAGNQPYCHCQPEYTGDRCQYY 4321 - 4357 YVCHHYCVNSESCTIGDDGSVECVCPTRYEGPKCEVD 4357 - 4392 DKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQLC 4390 - 4427 QLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCERP
Function	Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis
Motifs	MOTIF 4492 4495 Endocytosis signal. MOTIF 4559 4562 Endocytosis signal

Q9NZR2 Proteins EGF-like domain Repeats