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Q9UGI8 Proteins LIM zinc-binding domain Repeats
Uniprot ID:Q9UGI8
Protein name: Testin
Gene : TES
Protein Family:Prickle / espinas / testin family
Squence Length : 421
Sequnce
>Q9UGI8 422 MDLENKVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRMS
Domains
DOMAIN 92 199 PET DOMAIN 234 297 LIM zinc-binding 1 DOMAIN 299 359 LIM zinc-binding 2 DOMAIN 362 421 LIM zinc-binding 3
LIM zinc-binding sequence regions
234 - 297 CYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKP 299 - 359 CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVC 362 - 421 CHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRMS
Function
"Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth"
Mutation
328 328 C->A: Abolishes interaction with ACTL7A 391 391 C->A: Abolishes localization at focal adhesions