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Q9UGI9 Proteins CBS domain Repeats

Uniprot ID:Q9UGI9	Protein name: 5'-AMP-activated protein kinase subunit gamma-3	Gene : PRKAG3 AMPKG3
Protein Family:5'-AMP-activated protein kinase gamma subunit family	Squence Length : 489

Sequnce	>Q9UGI9 490 MEPGLEHALRRTPSWSSLGGSEHQEMSFLEQENSSSWPSPAVTSSSERIRGKRRAKALRWTRQKSVEEGEPPGQGEGPRSRPAAESTGLEATFPKTTPLAQADPAGVGTPPTGWDCLPSDCTASAAGSSTDDVELATEFPATEAWECELEGLLEERPALCLSPQAPFPKLGWDDELRKPGAQIYMRFMQEHTCYDAMATSSKLVIFDTMLEIKKAFFALVANGVRAAPLWDSKKQSFVGMLTITDFILVLHRYYRSPLVQIYEIEQHKIETWREIYLQGCFKPLVSISPNDSLFEAVYTLIKNRIHRLPVLDPVSGNVLHILTHKRLLKFLHIFGSLLPRPSFLYRTIQDLGIGTFRDLAVVLETAPILTALDIFVDRRVSALPVVNECGQVVGLYSRFDVIHLAAQQTYNHLDMSVGEALRQRTLCLEGVLSCQPHESLGEVIDRIAREQVHRLVLVDETQHLLGVVSLSDILQALVLSPAGIDALGA
Domains	DOMAIN 197 258 CBS 1 DOMAIN 280 340 CBS 2 DOMAIN 355 415 CBS 3 DOMAIN 427 486 CBS 4
CBS sequence regions	197 - 258 TSSKLVIFDTMLEIKKAFFALVANGVRAAPLWDSKKQSFVGMLTITDFILVLHRYYRSPLVQ 280 - 340 KPLVSISPNDSLFEAVYTLIKNRIHRLPVLDPVSGNVLHILTHKRLLKFLHIFGSLLPRPS 355 - 415 RDLAVVLETAPILTALDIFVDRRVSALPVVNECGQVVGLYSRFDVIHLAAQQTYNHLDMSV 427 - 486 EGVLSCQPHESLGEVIDRIAREQVHRLVLVDETQHLLGVVSLSDILQALVLSPAGIDALG
Function	"AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive"
Motifs	MOTIF 293 314 AMPK pseudosubstrate
Binding Site	"BINDING 225 225 AMP, ADP or ATP 2. BINDING 285 285 AMP, ADP or ATP 1. via amide nitrogen and carbonyl oxygen. BINDING 306 306 AMP 3. BINDING 325 325 AMP, ADP or ATP 2. BINDING 355 355 AMP 3. BINDING 360 360 AMP 3. via amide nitrogen and carbonyl oxygen. BINDING 424 424 AMP, ADP or ATP 2. BINDING 432 432 AMP, ADP or ATP 2. via amide nitrogen and carbonyl oxygen. BINDING 453 453 AMP 3"
Nucleotide Binding	"NP_BIND 242 245 AMP, ADP or ATP 1. NP_BIND 306 307 AMP, ADP or ATP 1. NP_BIND 381 382 AMP 3. NP_BIND 397 400 AMP, ADP or ATP 2. NP_BIND 453 454 AMP, ADP or ATP 2. NP_BIND 469 472 AMP 3"