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Q9UHP3 Proteins UIM domain Repeats

Uniprot ID:Q9UHP3	Protein name: Ubiquitin carboxyl-terminal hydrolase 25	Gene : USP25 USP21
Protein Family:Peptidase C19 family	Squence Length : 1055

Sequnce	>Q9UHP3 1056 MTVEQNVLQQSAAQKHQQTFLNQLREITGINDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRETGITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASSPPSGSIPSQTLPSTTEQQGALSSELPSTSPSSVAAISSRSVIHKPFTQSRIPPDLPMHPAPRHITEEELSVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYINDKAQFLIQEEFNKETGQPLVGIETLPPDLRDFVEEDNQRFEKELEEWDAQLAQKALQEKLLASQKLRESETSVTTAQAAGDPEYLEQPSRSDFSKHLKEETIQIITKASHEHEDKSPETVLQSAIKLEYARLVKLAQEDTPPETDYRLHHVVVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERCHNIMKVAQAKLEMIKPEEVNLEEYEEWHQDYRKFRETTMYLIIGLENFQRESYIDSLLFLICAYQNNKELLSKGLYRGHDEELISHYRRECLLKLNEQAAELFESGEDREVNNGLIIMNEFIVPFLPLLLVDEMEEKDILAVEDMRNRWCSYLGQEMEPHLQEKLTDFLPKLLDCSMEIKSFHEPPKLPSYSTHELCERFARIMLSLSRTPADGR
Domains	DOMAIN 14 57 UBA-like DOMAIN 97 116 UIM 1 DOMAIN 123 140 UIM 2 DOMAIN 169 657 USP
UIM sequence regions	97 - 116 KDDLQRAIALSLAESNRAFR 123 - 140 EEQAISRVLEASIAENKA
Function	"Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.; The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function"
Active Site	ACT_SITE 178 178 . ACT_SITE 599 599 . ACT_SITE 607 607
Motifs	MOTIF 89 95 Required for SUMO paralog-specific binding
Mutation	91 91 V->A: No interaction with SUMO3 when associated with A-92 92 92 I->A: No interaction with SUMO3 when associated with A-91 99 99 K->R: Abolishes sumoylation 178 178 C->S: Abrogates deubiquitinating activity 740 740 Y->F: No effect on interaction with SYK 878 878 T->I: No effect on interaction with SYK 880 880 Y->F: No effect on interaction with SYK 883 883 I->S: No effect on interaction with SYK