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Q9Y6I3 Proteins UIM domain Repeats
Uniprot ID:Q9Y6I3
Protein name: Epsin-1
Gene : EPN1
Protein Family:Epsin family
Squence Length : 576
Sequnce
>Q9Y6I3 577 MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQPPSCGPEDDAQLQLALSLSREEHDKEERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL
Domains
DOMAIN 12 144 ENTH DOMAIN 183 202 UIM 1 DOMAIN 208 227 UIM 2 DOMAIN 233 252 UIM 3
UIM sequence regions
183 - 202 ELQLQLALAMSKEEADQPPS 208 - 227 DAQLQLALSLSREEHDKEER 233 - 252 DLRLQMAIEESKRETGGKEE
Function
"Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis"
Motifs
"MOTIF 402 411 [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif"
Binding Site
BINDING 8 8 Phosphatidylinositol lipid headgroup. BINDING 11 11 Phosphatidylinositol lipid headgroup. BINDING 25 25 Phosphatidylinositol lipid headgroup. BINDING 30 30 Phosphatidylinositol lipid headgroup. BINDING 63 63 Phosphatidylinositol lipid headgroup. BINDING 73 73 Phosphatidylinositol lipid headgroup
Mutation
382 382 S->A: Abolishes phosphorylation by CDK1 382 382 S->D: Abolishes phosphorylation by CDK1 and reduces REPS2 binding 404 404 F->A: Reduces interaction with AP2B1