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Q9Y6M1 Proteins RRM domain Repeats
Uniprot ID:Q9Y6M1
Protein name: Insulin-like growth factor 2 mRNA-binding protein 2
Gene : IGF2BP2 IMP2 VICKZ2
Protein Family:RRM IMP/VICKZ family
Squence Length : 599
Sequnce
>Q9Y6M1 600 MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSGKVELHGKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVNTDTETAVVNVTYATREEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDLSIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSVLSPPAGPRGAPPAAPYHPFTTHSGYFSSLYPHHQFGPFPHHHSYPEQEIVNLFIPTQAVGAIIGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQEQKYPQGVASQRSK
Domains
DOMAIN 3 76 RRM 1 DOMAIN 82 157 RRM 2 DOMAIN 193 258 KH 1 DOMAIN 274 341 KH 2 DOMAIN 427 492 KH 3 DOMAIN 509 575 KH 4
RRM sequence regions
3 - 76 LYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSGKVELHGKIMEVDYSVSKK 82 - 157 IQIRNIPPHLQWEVLDGLLAQYGTVENVEQVNTDTETAVVNVTYATREEAKIAMEKLSGHQFENYSFKISYIPDEE
Function
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts
Mutation
"211 211 K->E: Significantly impaired binding to ACTB transcript, but little effect on MYC transcript binding, accumulation in the nucleus when associated with E-292 when associated with E-292 445-E-E-446 and 526-E-E-527 292 292 K->E: Significantly impaired binding to ACTB transcript, but little effect on MYC transcript binding, accumulation in the nucleus when associated with E-211 when associated with E-211 445-E-E-445 and 526-E-E-527 445 446 KK->EE: Significantly impaired binding to ACTB and MYC transcripts when associated with 527-E-E-528 when associated with E-211 E-292 and 527-E-E-528 527 528 KG->EE: Significantly impaired binding to ACTB and MYC transcripts when associated with 445-E-E-446 when associated with E-211 E-292 and 445-E-E-446"