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The Q9H0C8 Proteins with novel repeats

Uniprot ID:Q9H0C8	Gene name: ILKAP	Protein Family:PP2C family
Protein name: Integrin-linked kinase-associated serine/threonine phosphatase 2C	Length : 392

Sequnce	>Q9H0C8 393 MDLFGDLPEPERSPRPAAGKEAQKGPLLFDDLPPASSTDSGSGGPLLFDDLPPASSGDSGSLATSISQMVKTEGKGAKRKTSEEEKNGSEELVEKKVCKASSVIFGLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVVRIGH
T-REKS Repeated Sequence regions	Length: 19 residues : 3 times from 16 to 71 :0.6666666666666666 region Length:56 PAAGKEAQKG-PLLFDDLP PASSTDSGSGGPLLFDDLP PASSGDSGSLATSISQMVK
XSTREAM Repeated Sequence regions	Repeat Length:19; Regions:25-62 GPLLFDDLPPASSTDSGSG GPLLFDDLPPASSGDSGSL
Domains	DOMAIN 108 390 PPM-type phosphatase
Function	"Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation"
Mutation	152 152 D->A: Loss of >90% of activity 154 154 H->D: Loss of >90% of activity 154 154 H->L: Loss of >90% of activity