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The Q9H2D6 Proteins with novel repeats
Uniprot ID:Q9H2D6
Gene name: TRIOBP KIAA1662 TARA HRIHFB2122
Protein Family:
Protein name: TRIO and F-actin-binding protein
Length : 2365
Sequnce
>Q9H2D6 2366 MEEVPGDALCEHFEANILTQNRCQNCFHPEEAHGARYQELRSPSGAEVPYCDLPRCPPAPEDPLSASTSGCQSVVDPGLRPGPKRGPSPSAGLPEEGPTAAPRSRSRELEAVPYLEGLTTSLCGSCNEDPGSDPTSSPDSATPDDTSNSSSVDWDTVERQEEEAPSWDELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGGGGRSAGQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRITQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLFQDLPRASTESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLHGSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEAAGAFQAQDEGRSQQPSQGQSQLLRRQSSPAPSRQVTMLPAKQAELTRRSQAEPPHPWSPEKRPEGDRQLQGSPLPPRTSARTPERELRTQRPLESGQAGPRQPLGVWQSQEEPPGSQGPHRHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQPEAWEEKPTHELPRELGKRSPLTSPPENWGGPAESSQSWHSGTPTAVGWGAEGACPYPRGSERRPELDWRDLLGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPAGHRDDLARALGPELGPPGTNDVPEQESHSQPEGWAEATPVNGHSPALQSQSPVQLPSPACTSTQWPKIKVTRGPATATLAGLEQTGPLGSRSTAKGPSLPELQFQPEEPEESEPSRGQDPLTDQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE
T-REKS Repeated Sequence regions
Length: 24 residues : 20 times from 405 to 885 :0.7724137931034483 region Length:481 SCAQRDNPKASRTSSPNRAT-R-D-NPRT SCAQRDNPRAS--S-PSRAT-R-D-NPTT SCAQRDNPRASRTSSPNRAT-R-D-NPRT SCAQRDNPRAS--S-PSRAT-R-D-NPTT SCAQRDNPRASRTSSPNRAT-R-D-NPRT SCAQRDNPRAS--S-PNRAA-R-D-NPTT SCAQRDNPRASRTSSPNRAT-R-D-NPRT SCAQRDNPRAS--S-PNRAT-R-D-NPTT SCAQRDNPRASRTSSPNRAT-R-D-NPRT SCAQRDNPRAS--S-PNRTT-QQD-SPRT SCARRDDPRAS--S-PNRTI-QQE-NPRT SCALRDNPRAS--S-PSRTI-QQE-NPRT SCAQRDDPRAS--S-PNRTT-QQE-NPRT SCARRDNPRAS--SR-NRTIQR-D-NPRT SCAQRDNPRAS--S-PNRTI-QQE-NLRT SCTRQDNPR---TSSPNRAT-R-D-NPRT SCAQRDNLRAS--S-PIRAT-QQD-NPRT -CIQQNIPRSSSTQQDNPKT-S-C-TKR- -----DNLRPTCTQR-DR-T-Q-SFSFQR DNPGTSSSQCC-TQKENLRP---S-SPHR Length: 24 residues : 3 times from 887 to 967 :0.7023809523809523 region Length:81 TQWNNPRNSSPHRTNK-DIPWASFPLRP TQSDGPRTSSPSRSKQSEVPWASIALRP TQGDRPQTSSPSRPAQHDPPQSSFG--P
XSTREAM Repeated Sequence regions
Repeat Length:23; Regions:375-817 R-ENPRTPCVQQ-DDP---RA---SSPNRTTQ- R-ENSRTSCAQR-DNPKASRT---SSPNRAT-- R-DNPRTSCAQR-DNP---RA---SSPSRAT-- R-DNPTTSCAQR-DNP---RASRTSSPNRAT-- R-DNPRTSCAQR-DNP---RA---SSPSRAT-- R-DNPTTSCAQR-DNP---RASRTSSPNRAT-- R-DNPRTSCAQR-DNP---RA---SSPNRAA-- R-DNPTTSCAQR-DNP---RASRTSSPNRAT-- R-DNPRTSCAQR-DNP---RA---SSPNRAT-- R-DNPTTSCAQR-DNP---RASRTSSPNRAT-- R-DNPRTSCAQR-DNP---RA---SSPNRTTQ- Q-DSPRTSCARR-DDP---RA---SSPNR-TIQ Q-ENPRTSCALR-DNP---RA---SSPSR-TIQ Q-ENPRTSCAQR-DDP---RA---SSPNRTTQ- Q-ENPRTSCARR-DNP---RA---SSRNR-TIQ R-DNPRTSCAQR-DNP---RA---SSPNR-TIQ Q-ENLRTSC-TRQDNP---RT---SSPNRAT-- R-DNPRTSCAQR-DNL---RA---SSPIRAT-- QQDNPRT
Domains
DOMAIN 1778 1887 PH
Function
"May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover"
Disease
"DISEASE: Deafness, autosomal recessive, 28 (DFNB28) [MIM:609823]: A form of non-syndromic sensorineural hearing loss Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information Note=The disease is caused by mutations affecting the gene represented in this entry"