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Q8TF76 Proteins with novel repeats

Uniprot ID:Q8TF76	Gene name: HASPIN GSG2	Protein Family:"Protein kinase superfamily, Ser/Thr protein kinase family, Haspin subfamily"
Protein name: Serine/threonine-protein kinase haspin	Length : 798

Sequnce	>Q8TF76 799 MAASLPGPGSRLFRTYGAADGRRQRRPGREAAQWFPPQDRRRFFNSSGSSDASIGDPSQSDDPDDPDDPDFPGSPVRRRRRRPGGRVPKDRPSLTVTPKRWKLRARPSLTVTPRRLGLRARPPQKCSTPCGPLRLPPFPSRDSGRLSPDLSVCGQPRDGDELGISASLFSSLASPCPGSPTPRDSVISIGTSACLVAASAVPSGLHLPEVSLDRASLPCSQEEATGGAKDTRMVHQTRASLRSVLFGLMNSGTPEDSEFRADGKNMRESCCKRKLVVGNGPEGPGLSSTGKRRATGQDSCQERGLQEAVRREHQEASVPKGRIVPRGIDRLERTRSSRKSKHQEATETSLLHSHRFKKGQKLGKDSFPTQDLTPLQNVCFWTKTRASFSFHKKKIVTDVSEVCSIYTTATSLSGSLLSECSNRPVMNRTSGAPSSWHSSSMYLLSPLNTLSISNKKASDAEKVYGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK
Repeated Sequence regions	Length: 15 residues : 3 times from 91 to 135 :0.7254901960784313 region Length:45 RPSLTV-TPKRWKL-RA RPSLTV-TPRRLGL-RA RPPQKCSTP--CGPLRL
Domains	DOMAIN 484 798 Protein kinase
Function	"Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle"
Active Site	ACT_SITE 649 649 Proton acceptor
Binding Site	BINDING 511 511 ATP
Nucleotide Binding	NP_BIND 490 498 ATP. NP_BIND 606 611 ATP. NP_BIND 649 654 ATP. NP_BIND 687 689 ATP
Mutation	"492 492 E->A: Markedly reduced affinity for histone H3 and reduced histone H3 phosphorylation 511 511 K->A: Strongly reduced enzyme activity 651 651 H->A: Strongly reduced enzyme activity, markedly reduced affinity for histone H3 707 707 D->L: Markedly reduced affinity for histone H3 and reduced histone H3 phosphorylation 709 709 D->N: Markedly reduced affinity for histone H3 and reduced histone H3 phosphorylation 713 713 G->F: Markedly reduced affinity for histone H3 and reduced histone H3 phosphorylation 716 716 D->L: Markedly reduced histone H3 phosphorylation"