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Q9H0C8 Proteins with novel repeats
Uniprot ID:Q9H0C8
Gene name: ILKAP
Protein Family:PP2C family
Protein name: Integrin-linked kinase-associated serine/threonine phosphatase 2C
Length : 392
Sequnce
>Q9H0C8 393 MDLFGDLPEPERSPRPAAGKEAQKGPLLFDDLPPASSTDSGSGGPLLFDDLPPASSGDSGSLATSISQMVKTEGKGAKRKTSEEEKNGSEELVEKKVCKASSVIFGLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVVRIGH
Repeated Sequence regions
Length: 19 residues : 3 times from 16 to 71 :0.6666666666666666 region Length:56 PAAGKEAQKG-PLLFDDLP PASSTDSGSGGPLLFDDLP PASSGDSGSLATSISQMVK
Domains
DOMAIN 108 390 PPM-type phosphatase
Function
"Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation"
Mutation
152 152 D->A: Loss of >90% of activity 154 154 H->D: Loss of >90% of activity 154 154 H->L: Loss of >90% of activity