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Q9NY25 Proteins with novel repeats
Uniprot ID:Q9NY25
Gene name: CLEC5A CLECSF5 MDL1
Protein Family:
Protein name: C-type lectin domain family 5 member A
Length : 188
Sequnce
>Q9NY25 189 MNWHMIISGLIVVVLKVVGMTLFLLYFPQIFNKSNDGFTTTRSYGTVSQIFGSSSPSPNGFITTRSYGTVCPKDWEFYQARCFFLSTSESSWNESRDFCKGKGSTLAIVNTPEKLKFLQDITDAEKYFIGLIYHREEKRWRWINNSVFNGNVTNQNQNFNCATIGLTKTFDAASCDISYRRICEKNAK
Repeated Sequence regions
Length: 20 residues : 2 times from 29 to 68 :0.7608695652173914 region Length:40 QIF-NKS-N-DGFTTTRSYGTVS QIFGSSSPSPNGFITTRSYG---
Domains
DOMAIN 78 184 C-type lectin
Function
"Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4.; (Microbial infection) May act as a receptor for dengue virus on macrophages. The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release"
Mutation
16 16 K->I: Abolishes interaction with TYROBP