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P37231 of Proteins NR C4-type domain repeats

Uniprot ID:P37231	Protein name: Peroxisome proliferator-activated receptor gamma	Gene : PPARG NR1C3
Protein Family:"Nuclear hormone receptor family, NR1 subfamily"	Squence Length : 505

Sequnce	>P37231 506 MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
NR C4-type domains repeats	ZN_FING 139 159 NR C4-type ZN_FING 176 198 NR C4-type
Domin repeated regions	139 - 159 CRVCGDKASGFHYGVHACEGC 176 - 198 CDLNCRIHKKSRNKCQYCRFQKC
Function	"Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).; (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein"
Binding Site	BINDING 317 317 Synthetic agonist. BINDING 351 351 Synthetic agonist. BINDING 477 477 Synthetic agonist. BINDING 501 501 Synthetic agonist
Disease	"DISEASE: Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension PPARG mutations may be associated with colon cancer ; DISEASE: Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry ; DISEASE: Lipodystrophy, familial partial, 3 (FPLD3) [MIM:604367]: A form of lipodystrophy characterized by marked loss of subcutaneous fat from the extremities Facial adipose tissue may be increased, decreased or normal Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia Note=The disease is caused by mutations affecting the gene represented in this entry ; DISEASE: Glioma 1 (GLM1) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility"