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P55055 of Proteins NR C4-type domain repeats
Uniprot ID:P55055
Protein name: Oxysterols receptor LXR-beta
Gene : NR1H2 LXRB NER UNR
Protein Family:"Nuclear hormone receptor family, NR1 subfamily"
Squence Length : 460
Sequnce
>P55055 461 MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
NR C4-type domains repeats
ZN_FING 87 107 NR C4-type ZN_FING 125 149 NR C4-type
Domin repeated regions
87 - 107 CRVCGDKASGFHYNVLSCEGC 125 - 149 CRGGGTCQMDAFMRRKCQQCRLRKC
Function
"Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957)"
Mutation
409 409 K->R: Impaired ability to act as an anti-inflammatory role during the hepatic acute phase response when associated with R-447 447 447 K->R: Impaired ability to act as an anti-inflammatory role during the hepatic acute phase response when associated with R-409