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P55197 of Proteins PHD-type domain repeats
Uniprot ID:P55197
Protein name: Protein AF-10
Gene : MLLT10 AF10
Protein Family:
Squence Length : 1068
Sequnce
>P55197 1069 MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGLPSTSAVTSQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANTLSGSSLSQAPSHMYGNRSNSSMAALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQPGNSSLENLPPVAASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVMQTPVTMSQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQILIHQQQFQQLLNSQQLTPEQHQAFLYQLMQHHHQQHHQPELQQLQIPGPTQIPINNLLAGTQAPPLHTATTNPFLTIHGDNASQKVARLSDKTGPVAQEKS
PHD-type domains repeats
ZN_FING 22 74 PHD-type 1 ZN_FING 79 112 C2HC pre-PHD-type ZN_FING 135 198 PHD-type 2
Domin repeated regions
22 - 74 IGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRKCESQ 79 - 112 RVRCELCPHKDGALKRTDNGGWAHVVCALYIPEV 135 - 198 KTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHF
Function
"Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302)"
Mutation
22 22 I->A: Does not affect interaction with histone H3 80 80 V->A: Does not affect interaction with histone H3 106 106 A->V: Impairs interaction with histone H3 107 107 L->A: Impairs interaction with histone H3 109 109 I->A: Impairs interaction with histone H3 114 114 F->A: Impairs interaction with histone H3 120 120 M->A: Impairs interaction with histone H3 179 179 E->A: Impairs interaction with histone H3 190 190 Y->A: Impairs interaction with histone H3
Disease
DISEASE: Note=A chromosomal aberration involving MLLT10 is associated with acute leukemias Translocation t(10;11)(p12;q23) with KMT2A/MLL1 The result is a rogue activator protein ; DISEASE: Note=A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas Translocation t(10;11)(p13;q14) with PICALM