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Q07869 of Proteins NR C4-type domain repeats

Uniprot ID:Q07869	Protein name: Peroxisome proliferator-activated receptor alpha	Gene : PPARA NR1C1 PPAR
Protein Family:"Nuclear hormone receptor family, NR1 subfamily"	Squence Length : 468

Sequnce	>Q07869 469 MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
NR C4-type domains repeats	ZN_FING 102 122 NR C4-type ZN_FING 139 161 NR C4-type
Domin repeated regions	102 - 122 CRICGDKASGYHYGVHACEGC 139 - 161 CDRSCKIQKKNRNKCQYCRFHKC
Function	"Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2"
Binding Site	BINDING 280 280 Synthetic agonist. BINDING 314 314 Synthetic agonist. BINDING 440 440 Synthetic agonist. BINDING 464 464 Synthetic agonist
Mutation	"122 122 C->G: Prevents DNA binding but no effect on heterodimerization with RXRA 304 304 D->A: Reduced heterodimerization with RXRA 370 370 L->R: Abolishes heterodimerization with RXRA 391 391 L->R: Abolishes heterodimerization with RXRA 422 422 L->R: No effect on heterodimerization with RXRA nor on DNA binding and transactivation activity 431 431 A->T: No effect on heterodimerization with RXRA nor on DNA binding 433 433 L->R: Abolishes heterodimerization with RXRA, DNA binding and transactivation activity"