HOME
BACK
Q12933 of Proteins TRAF-type domain repeats
Uniprot ID:Q12933
Protein name: TNF receptor-associated factor 2
Gene : TRAF2 TRAP3
Protein Family:"TNF receptor-associated factor family, A subfamily"
Squence Length : 501
Sequnce
>Q12933 502 MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL
TRAF-type domains repeats
ZN_FING 34 73 RING-type ZN_FING 124 180 TRAF-type 1 ZN_FING 177 233 TRAF-type 2
Domin repeated regions
124 - 180 CHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHE 177 - 233 AHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQ
Function
"Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE"
Mutation
11 11 S->A: Reduces global phosphorylation 11 11 S->D: Slight increase of TNF-dependent activation of NF-kappa-B and activation of JNK 31 31 K->R: Abolishes 'Lys-63'-linked polyubiquitination 117 117 T->A: Loss of phosphorylation site 285 285 I->A: Strongly reduced interaction with BIRC3 288 288 V->A: Strongly reduced interaction with BIRC3 292 292 E->A: Strongly reduced interaction with BIRC3